How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health

How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health

Abstract Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethy...

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Bibliographic Details
Main Authors: Ayazhan Akhatova, Celine Jones, Kevin Coward, Marc Yeste
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Clinical Epigenetics
Subjects:
Sperm
Epigenetics
Lifestyle
Environmental factors
Offspring health
Online Access:https://doi.org/10.1186/s13148-025-01815-1
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