Exosomes derived from ccRCC cells confers fibroblasts activation to foster tumor progression through Warburg effect by downregulating PANK3

Abstract The interaction between tumor-derived exosomes and stroma plays a crucial role in tumor progression. However, the mechanisms through which tumor cells influence stromal changes are not yet fully understood. In our study, through single-cell sequencing analysis of clear cell renal cell carci...

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Bibliographic Details
Main Authors: Yang Yang, Cheng Qiang, Zhu Jie, Han Ce, Huang Yan, Li Xiu-bin, Fan Wen-mei, Zhang Xu, Gao Yu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02434-8
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