Insertion sequences accelerate genomic convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae via capsular phase variation

Insertion sequences accelerate genomic convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae via capsular phase variation

Abstract Background The convergence of resistance and hypervirulence in Klebsiella pneumoniae represents a significant public health threat, driven by the horizontal transfer of plasmids. Understanding factors affecting plasmid transfer efficiency is essential to elucidate mechanisms behind emergenc...

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Bibliographic Details
Main Authors: Da-Wei Wei, Yuqin Song, Yi Li, Gang Zhang, Qi Chen, Linhuan Wu, Jiangqing Huang, Xueru Tian, Chao Wang, Jie Feng
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
Subjects:
Carbapenem-resistant hypervirulent Klebsiella pneumoniae
Insertion sequence
Capsular phase variation
Genomic convergence
Online Access:https://doi.org/10.1186/s13073-025-01474-0
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