Heme oxygenase 1 confers gilteritinib resistance in FLT3-ITD acute myeloid leukemia in a STAT6-dependent manner

Heme oxygenase 1 confers gilteritinib resistance in FLT3-ITD acute myeloid leukemia in a STAT6-dependent manner

Abstract Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. We previously discovered that heme oxygenase 1 (HO1) is crucial for chemoresistance in AML, but the detailed molecular mechanism of that remains unclear. Methods RNA sequencing was conducted to asse...

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Bibliographic Details
Main Authors: Tianzhuo Zhang, Danna Wei, Yun Zhan, Zhengmei Long, Tingting Lu, Peng Zhao, Rui Gao, Qian Kang, Luxin Zhang, Min Liu, Xueying Yang, Jishi Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer Cell International
Subjects:
Heme Oxygenase 1
Acute myeloid leukemia
FLT3-ITD mutation
Gilteritinib resistance
STAT6
Online Access:https://doi.org/10.1186/s12935-025-03757-3
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https://doi.org/10.1186/s12935-025-03757-3

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