A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study
ObjectivePrevious studies have found that the relationship between metabolic indicators and Hashimoto’s thyroiditis (HT) in non-diabetic adults remains unclear. This study aims to explore the association between metabolic indicators and HT, providing new theoretical insights for the clinical managem...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1514857/full |
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| author | Manli Yan Wenhua Shi Ping Gong Yunsi Xie Kaiyuan Zhang Xiang Li Hua Wei Hua Wei |
| author_facet | Manli Yan Wenhua Shi Ping Gong Yunsi Xie Kaiyuan Zhang Xiang Li Hua Wei Hua Wei |
| author_sort | Manli Yan |
| collection | DOAJ |
| description | ObjectivePrevious studies have found that the relationship between metabolic indicators and Hashimoto’s thyroiditis (HT) in non-diabetic adults remains unclear. This study aims to explore the association between metabolic indicators and HT, providing new theoretical insights for the clinical management of HT.MethodsClinical data were collected from 2,015 non-diabetic adults at Guangdong Provincial Hospital of Chinese Medicine. The relationship between metabolic indicators and HT was analyzed using SPSS 26.0, R (version 4.2.1), and Zstats.ResultsAmong the 2,015 non-diabetic adult participants included in the study, 1,877 were in the non-HT group, while 138 were in the HT group. Significant differences were observed in metabolic indicators, including serum uric acid (SUA), serum creatinine (SCr), albumin (ALB) and high-density lipoprotein cholesterol (HDL-C), between the two groups, with statistical significance. A binary logistic regression model was established, revealing that SCr had a significant impact in both univariate and multivariate analyses. To further investigate the relationship between metabolic indicators and HT, we conducted a restricted cubic spline (RCS) analysis. The results demonstrated a clear non-linear relationship between SUA and HT, both before and after adjustment (All P < 0.01). Therefore, based on the inflection points derived from the RCS analysis, a segmented logistic regression analysis was performed. The findings indicated a significant association between both low and high levels of SUA and HT (Lower OR: 2.043; 95% CI: 1.405-3.019; P < 0.001; Higher OR: 2.369; 95% CI: 0.998-4.999; P = 0.034).ConclusionThis study is the first to reveal a U-shaped association between SUA levels and the risk of HT, suggesting that maintaining SUA levels within the range of 359.0-540.0 μmol/L may help reduce the risk of HT occurrence. This finding provides a new perspective for early intervention and long-term management of HT, particularly in terms of SUA regulation in HT patients, which holds potential clinical value. |
| format | Article |
| id | doaj-art-86e31a3ec2f74ddfb1af514a5607f602 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-86e31a3ec2f74ddfb1af514a5607f6022025-02-04T10:33:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15148571514857A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional studyManli Yan0Wenhua Shi1Ping Gong2Yunsi Xie3Kaiyuan Zhang4Xiang Li5Hua Wei6Hua Wei7Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaDepartment of Endocrinology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaObjectivePrevious studies have found that the relationship between metabolic indicators and Hashimoto’s thyroiditis (HT) in non-diabetic adults remains unclear. This study aims to explore the association between metabolic indicators and HT, providing new theoretical insights for the clinical management of HT.MethodsClinical data were collected from 2,015 non-diabetic adults at Guangdong Provincial Hospital of Chinese Medicine. The relationship between metabolic indicators and HT was analyzed using SPSS 26.0, R (version 4.2.1), and Zstats.ResultsAmong the 2,015 non-diabetic adult participants included in the study, 1,877 were in the non-HT group, while 138 were in the HT group. Significant differences were observed in metabolic indicators, including serum uric acid (SUA), serum creatinine (SCr), albumin (ALB) and high-density lipoprotein cholesterol (HDL-C), between the two groups, with statistical significance. A binary logistic regression model was established, revealing that SCr had a significant impact in both univariate and multivariate analyses. To further investigate the relationship between metabolic indicators and HT, we conducted a restricted cubic spline (RCS) analysis. The results demonstrated a clear non-linear relationship between SUA and HT, both before and after adjustment (All P < 0.01). Therefore, based on the inflection points derived from the RCS analysis, a segmented logistic regression analysis was performed. The findings indicated a significant association between both low and high levels of SUA and HT (Lower OR: 2.043; 95% CI: 1.405-3.019; P < 0.001; Higher OR: 2.369; 95% CI: 0.998-4.999; P = 0.034).ConclusionThis study is the first to reveal a U-shaped association between SUA levels and the risk of HT, suggesting that maintaining SUA levels within the range of 359.0-540.0 μmol/L may help reduce the risk of HT occurrence. This finding provides a new perspective for early intervention and long-term management of HT, particularly in terms of SUA regulation in HT patients, which holds potential clinical value.https://www.frontiersin.org/articles/10.3389/fendo.2025.1514857/fullHashimoto’s thyroiditisnon-diabetic adultsserum uric acidRCS analysisU-shaped curve |
| spellingShingle | Manli Yan Wenhua Shi Ping Gong Yunsi Xie Kaiyuan Zhang Xiang Li Hua Wei Hua Wei A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study Frontiers in Endocrinology Hashimoto’s thyroiditis non-diabetic adults serum uric acid RCS analysis U-shaped curve |
| title | A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study |
| title_full | A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study |
| title_fullStr | A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study |
| title_full_unstemmed | A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study |
| title_short | A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study |
| title_sort | u shaped non linear association between serum uric acid levels and the risk of hashimoto s thyroiditis a cross sectional study |
| topic | Hashimoto’s thyroiditis non-diabetic adults serum uric acid RCS analysis U-shaped curve |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1514857/full |
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