Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement
Purpose. Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis. There is convincing evidence from many studies that left atrium fibrosis is...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/1358098 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850215802503954432 |
|---|---|
| author | Wei Hu Jing Xie Tongjian Zhu Guannan Meng Meng Wang Zhen Zhou Fuding Guo Hui Chen Zhuo Wang Songyun Wang Huafen Liu Hong Jiang |
| author_facet | Wei Hu Jing Xie Tongjian Zhu Guannan Meng Meng Wang Zhen Zhou Fuding Guo Hui Chen Zhuo Wang Songyun Wang Huafen Liu Hong Jiang |
| author_sort | Wei Hu |
| collection | DOAJ |
| description | Purpose. Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis. There is convincing evidence from many studies that left atrium fibrosis is involved in the pathophysiology of AF. Therefore, we speculated that Neu5Ac may be associated with atrial fibrillation (AF) and involved in the development of AF. This study aims to investigate the clinical relationship between Neu5Ac and AF and left atrial enlargement. Methods. Forty-five patients with AF (AF group) and forty-five patients with non-AF (control group) matched for age, sex, and hospitalization date were recruited for our study. Plasma concentrations of Neu5Ac from peripheral venous blood were analyzed using enzyme-linked immunosorbent assay (ELISA). The baseline characteristics, plasma level of Neu5Ac, and echocardiographic characteristics were evaluated. Results. The plasma level of Neu5Ac was significantly higher in the AF group than in the control group (107.66 ± 47.50 vs 77.87 ± 39.09 ng/ml; P<0.05); the left atrial diameters were positively correlated with the plasma Neu5Ac level (R = 0.255; P<0.05). The plasma Neu5Ac level (R = 0.368; P<0.05) and the left atrial diameters (R = 0.402; P<0.05) were positively correlated with AF history times. Neu5Ac (odds ratio 1.018, 95% CI 1.003–1.032; P<0.05) and the left atrial diameter (odds ratio 1.142, 95% CI 1.020–1.280; P<0.05) were independent risk factors for AF in multivariate regression analysis. Conclusions. Serum Neu5Ac is associated with atrial fibrillation, and the mechanism may involve left atrial enlargement. |
| format | Article |
| id | doaj-art-86e30f8684ec4959b653e03d49e78e2e |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-86e30f8684ec4959b653e03d49e78e2e2025-08-20T02:08:31ZengWileyCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/13580981358098Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial EnlargementWei Hu0Jing Xie1Tongjian Zhu2Guannan Meng3Meng Wang4Zhen Zhou5Fuding Guo6Hui Chen7Zhuo Wang8Songyun Wang9Huafen Liu10Hong Jiang11Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, ChinaPurpose. Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis. There is convincing evidence from many studies that left atrium fibrosis is involved in the pathophysiology of AF. Therefore, we speculated that Neu5Ac may be associated with atrial fibrillation (AF) and involved in the development of AF. This study aims to investigate the clinical relationship between Neu5Ac and AF and left atrial enlargement. Methods. Forty-five patients with AF (AF group) and forty-five patients with non-AF (control group) matched for age, sex, and hospitalization date were recruited for our study. Plasma concentrations of Neu5Ac from peripheral venous blood were analyzed using enzyme-linked immunosorbent assay (ELISA). The baseline characteristics, plasma level of Neu5Ac, and echocardiographic characteristics were evaluated. Results. The plasma level of Neu5Ac was significantly higher in the AF group than in the control group (107.66 ± 47.50 vs 77.87 ± 39.09 ng/ml; P<0.05); the left atrial diameters were positively correlated with the plasma Neu5Ac level (R = 0.255; P<0.05). The plasma Neu5Ac level (R = 0.368; P<0.05) and the left atrial diameters (R = 0.402; P<0.05) were positively correlated with AF history times. Neu5Ac (odds ratio 1.018, 95% CI 1.003–1.032; P<0.05) and the left atrial diameter (odds ratio 1.142, 95% CI 1.020–1.280; P<0.05) were independent risk factors for AF in multivariate regression analysis. Conclusions. Serum Neu5Ac is associated with atrial fibrillation, and the mechanism may involve left atrial enlargement.http://dx.doi.org/10.1155/2020/1358098 |
| spellingShingle | Wei Hu Jing Xie Tongjian Zhu Guannan Meng Meng Wang Zhen Zhou Fuding Guo Hui Chen Zhuo Wang Songyun Wang Huafen Liu Hong Jiang Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement Cardiology Research and Practice |
| title | Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement |
| title_full | Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement |
| title_fullStr | Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement |
| title_full_unstemmed | Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement |
| title_short | Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement |
| title_sort | serum n acetylneuraminic acid is associated with atrial fibrillation and left atrial enlargement |
| url | http://dx.doi.org/10.1155/2020/1358098 |
| work_keys_str_mv | AT weihu serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT jingxie serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT tongjianzhu serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT guannanmeng serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT mengwang serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT zhenzhou serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT fudingguo serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT huichen serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT zhuowang serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT songyunwang serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT huafenliu serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement AT hongjiang serumnacetylneuraminicacidisassociatedwithatrialfibrillationandleftatrialenlargement |