Establishment of a Rat Model of Alzheimer's Disease by Introducing Human Triple Mutant APP Gene into Hippocampus via Brain Stereotactic Technology

Establishment of a Rat Model of Alzheimer's Disease by Introducing Human Triple Mutant APP Gene into Hippocampus via Brain Stereotactic Technology

Objective To establish a rat model of Alzheimer's disease (AD) expressing human triple mutant amyloid precursor protein (APP) in the hippocampus, and to provide a model for the study of disease mechanisms and drug development. Methods Twenty-four 12-week-old SPF-grade female SD rats were random...

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Bibliographic Details
Main Authors: XIAO Linlin, YANG Yixuan, LI Shanshan, LUO Lanshiyu, YIN Siwei, SUN Juming, SHI Wei, OUYANG Yiqiang, LI Xiyi
Format: Article
Language:zho
Published: Editorial Office of Laboratory Animal and Comparative Medicine 2025-06-01
Series:Shiyan dongwu yu bijiao yixue
Subjects:
alzheimer's disease
amyloid precursor protein
human triple mutant gene
brain stereotaxis
rat model
Online Access:https://www.slarc.org.cn/dwyx/article/2025/1674-5817/1674-5817-2025-45-3-269.shtml
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