In Vivo Radionuclide Generators for Diagnostics and Therapy
In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therape...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2016/6148357 |
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| _version_ | 1850215801658802176 |
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| author | Patricia E. Edem Jesper Fonslet Andreas Kjær Matthias Herth Gregory Severin |
| author_facet | Patricia E. Edem Jesper Fonslet Andreas Kjær Matthias Herth Gregory Severin |
| author_sort | Patricia E. Edem |
| collection | DOAJ |
| description | In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived α-emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains. |
| format | Article |
| id | doaj-art-86e0aef37d7f43ca8bf057c0696dea56 |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-86e0aef37d7f43ca8bf057c0696dea562025-08-20T02:08:31ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2016-01-01201610.1155/2016/61483576148357In Vivo Radionuclide Generators for Diagnostics and TherapyPatricia E. Edem0Jesper Fonslet1Andreas Kjær2Matthias Herth3Gregory Severin4Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Nuclear Technologies, Technical University of Denmark, Roskilde, DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, DenmarkDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Nuclear Technologies, Technical University of Denmark, Roskilde, DenmarkIn vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived α-emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.http://dx.doi.org/10.1155/2016/6148357 |
| spellingShingle | Patricia E. Edem Jesper Fonslet Andreas Kjær Matthias Herth Gregory Severin In Vivo Radionuclide Generators for Diagnostics and Therapy Bioinorganic Chemistry and Applications |
| title | In Vivo Radionuclide Generators for Diagnostics and Therapy |
| title_full | In Vivo Radionuclide Generators for Diagnostics and Therapy |
| title_fullStr | In Vivo Radionuclide Generators for Diagnostics and Therapy |
| title_full_unstemmed | In Vivo Radionuclide Generators for Diagnostics and Therapy |
| title_short | In Vivo Radionuclide Generators for Diagnostics and Therapy |
| title_sort | in vivo radionuclide generators for diagnostics and therapy |
| url | http://dx.doi.org/10.1155/2016/6148357 |
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