Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro
Both in vitro and in vivo models have demonstrated that some parasites can interfere with tumor cell growth. The present study investigates the anticancer activity of hydatid cyst protoscolices on WEHI-164 fibrosarcoma cells and baby hamster kidney (BHK) fibroblast cells in vitro. Those above two c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/304183 |
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| author | Hossein Yousofi Darani Narges Soozangar Soliman Khorami Fatomeh Taji Mortaza Yousofi Hedayatollah Shirzad |
| author_facet | Hossein Yousofi Darani Narges Soozangar Soliman Khorami Fatomeh Taji Mortaza Yousofi Hedayatollah Shirzad |
| author_sort | Hossein Yousofi Darani |
| collection | DOAJ |
| description | Both in vitro and in vivo models have demonstrated that some parasites can interfere with tumor cell growth. The present study investigates the anticancer activity of hydatid cyst protoscolices on WEHI-164 fibrosarcoma cells and baby hamster kidney (BHK) fibroblast cells in vitro. Those above two cell types were treated with live hydatid cyst protoscolices or left untreated for control groups. After 48 h, lactate dehydrogenase (LDH) and cell counts were assayed for both treated cells and control groups. Following treatment with hydatid cyst protoscolices, cell proliferation of both cell types was inhibited, and lysis of fibrosarcoma cells increased. Based on these results, it appears that hydatid cyst protoscolices have strong anticancer activity, and additional studies are needed to further clarify the mechanisms of this activity. |
| format | Article |
| id | doaj-art-86e079a02b714a5e82c62f22ab3338b8 |
| institution | OA Journals |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-86e079a02b714a5e82c62f22ab3338b82025-08-20T02:08:31ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/304183304183Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In VitroHossein Yousofi Darani0Narges Soozangar1Soliman Khorami2Fatomeh Taji3Mortaza Yousofi4Hedayatollah Shirzad5Department of Parasitology, Cell and Molecular Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Immunology, Cell and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranBoth in vitro and in vivo models have demonstrated that some parasites can interfere with tumor cell growth. The present study investigates the anticancer activity of hydatid cyst protoscolices on WEHI-164 fibrosarcoma cells and baby hamster kidney (BHK) fibroblast cells in vitro. Those above two cell types were treated with live hydatid cyst protoscolices or left untreated for control groups. After 48 h, lactate dehydrogenase (LDH) and cell counts were assayed for both treated cells and control groups. Following treatment with hydatid cyst protoscolices, cell proliferation of both cell types was inhibited, and lysis of fibrosarcoma cells increased. Based on these results, it appears that hydatid cyst protoscolices have strong anticancer activity, and additional studies are needed to further clarify the mechanisms of this activity.http://dx.doi.org/10.1155/2012/304183 |
| spellingShingle | Hossein Yousofi Darani Narges Soozangar Soliman Khorami Fatomeh Taji Mortaza Yousofi Hedayatollah Shirzad Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro Journal of Parasitology Research |
| title | Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro |
| title_full | Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro |
| title_fullStr | Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro |
| title_full_unstemmed | Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro |
| title_short | Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney Fibroblasts In Vitro |
| title_sort | hydatid cyst protoscolices induce cell death in wehi 164 fibrosarcoma cells and inhibit the proliferation of baby hamster kidney fibroblasts in vitro |
| url | http://dx.doi.org/10.1155/2012/304183 |
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