Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

BackgroundDysregulation of immune responses may influence the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH). Our recent data suggest the role of Th17-related cytokines in fibrosis advancement in MASLD. Herei...

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Bibliographic Details
Main Authors: Elżbieta Supruniuk, Kamil Grubczak, Anna Parfieniuk-Kowerda, Robert Flisiak, Marcin Moniuszko, Jerzy Jaroszewicz, Adrian Chabowski, Magdalena Świderska
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
metabolic dysfunction-associated steatotic liver disease
Th17 CD4+ T-cells
T-regulatory cells
fibrosis
IL-10
IL-17A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597204/full
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