Case Report: “DEK::AFF2 fusion associated sinonasal carcinomas: a novel oncogenic driver and emerging therapeutic strategies”

Case Report: “DEK::AFF2 fusion associated sinonasal carcinomas: a novel oncogenic driver and emerging therapeutic strategies”

BackgroundDEK::AFF2 fusion-associated carcinomas of the sinonasal tract are exceedingly rare, with fewer than 100 cases reported worldwide, but probably underrecognized. Recently classified by the WHO as a distinct provisional subtype of non-keratinizing squamous cell carcinoma, these tumors pose si...

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Bibliographic Details
Main Authors: Moritz Knebel, Abbas Agaimy, Jan Philipp Kühn, Sandrina Körner, Felix Braun, Lukas Brust, Veronika Flockerzi, Silke Wemmert, Benedikt Balensiefer, Bernhard Schick, Umut Yilmaz, Malek Zaito, Alessandro Bozzato, Maximilian Linxweiler
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
DEK::AFF2 fusion
sinonasal cancer
neoadjuvant chemo(radio)therapy
prognosis
diagnostic
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1611790/full
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