Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats
Background and aims: Hypothyroidism and cardiovascular diseases are associated with oxidative stress. Vitamin C is widely recognized for its antioxidant properties. This study aimed to investigate the effects of vitamin C during the neonatal and juvenile periods on oxidative stress induced by hyp...
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Shahrekord University of Medical Sciences
2024-12-01
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| Series: | Future Natural Products |
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| Online Access: | http://fnp.skums.ac.ir/Article/fnp-183 |
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| author | Farimah Beheshti Reza Mohebbati Mahmoud Hosseini Saeed Niazmand Masomeh Mirzaei Mahdiyeh Hedayati-Moghadam Maryam Paseban |
| author_facet | Farimah Beheshti Reza Mohebbati Mahmoud Hosseini Saeed Niazmand Masomeh Mirzaei Mahdiyeh Hedayati-Moghadam Maryam Paseban |
| author_sort | Farimah Beheshti |
| collection | DOAJ |
| description | Background and aims: Hypothyroidism and cardiovascular diseases are associated with
oxidative stress. Vitamin C is widely recognized for its antioxidant properties. This study aimed
to investigate the effects of vitamin C during the neonatal and juvenile periods on oxidative stress
induced by hypothyroidism in the hearts of rats.
Methods: Sixteen pregnant rats were randomly divided into five groups after delivery: a control
group, a group receiving propylthiouracil (PTU), and three treatment groups receiving PTU
along with 10, 100, and 500 mg/kg of vitamin C. The experimental treatments continued for
the first eight weeks of the offspring’s life, following the lactation period, and the offspring were
treated in the same manner. At the end of the study, the rats were sacrificed, and serum, aortic,
and cardiac tissues were collected for antioxidant evaluation.
Results: In the group receiving PTU, levels of thyroxine and antioxidant enzymes were decreased
in serum, heart, and aortic tissues. In contrast, the groups receiving PTU along with various
doses of vitamin C demonstrated an attenuation of these parameters.
Conclusion: Based on the findings, vitamin C supplementation improved cardiovascular
oxidative stress induced by hypothyroidism in rats. |
| format | Article |
| id | doaj-art-86ca1607db9c4355b8551f0bfe9b76c0 |
| institution | OA Journals |
| issn | 2783-4662 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Future Natural Products |
| spelling | doaj-art-86ca1607db9c4355b8551f0bfe9b76c02025-08-20T02:35:43ZengShahrekord University of Medical SciencesFuture Natural Products2783-46622024-12-01101152110.34172/fnp.183Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile ratsFarimah Beheshti0https://orcid.org/0000-0003-1524-2339Reza Mohebbati1https://orcid.org/0000-0002-1645-7094Mahmoud Hosseini2https://orcid.org/0000-0002-9843-3394Saeed Niazmand3https://orcid.org/0000-0001-6595-8170Masomeh Mirzaei4https://orcid.org/0000-0003-0702-3961Mahdiyeh Hedayati-Moghadam5https://orcid.org/0000-0002-7058-481XMaryam Paseban6https://orcid.org/0000-0002-6183-8697Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, IranDepartment of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, IranDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranRheumatic Diseases Research Centre, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, IranInnovative Medical Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Islamic Azad University, Mashhad, Iran / Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, IranBackground and aims: Hypothyroidism and cardiovascular diseases are associated with oxidative stress. Vitamin C is widely recognized for its antioxidant properties. This study aimed to investigate the effects of vitamin C during the neonatal and juvenile periods on oxidative stress induced by hypothyroidism in the hearts of rats. Methods: Sixteen pregnant rats were randomly divided into five groups after delivery: a control group, a group receiving propylthiouracil (PTU), and three treatment groups receiving PTU along with 10, 100, and 500 mg/kg of vitamin C. The experimental treatments continued for the first eight weeks of the offspring’s life, following the lactation period, and the offspring were treated in the same manner. At the end of the study, the rats were sacrificed, and serum, aortic, and cardiac tissues were collected for antioxidant evaluation. Results: In the group receiving PTU, levels of thyroxine and antioxidant enzymes were decreased in serum, heart, and aortic tissues. In contrast, the groups receiving PTU along with various doses of vitamin C demonstrated an attenuation of these parameters. Conclusion: Based on the findings, vitamin C supplementation improved cardiovascular oxidative stress induced by hypothyroidism in rats.http://fnp.skums.ac.ir/Article/fnp-183vitamin cpropylthiouracilhypothyroidismcardiovascularoxidative stress |
| spellingShingle | Farimah Beheshti Reza Mohebbati Mahmoud Hosseini Saeed Niazmand Masomeh Mirzaei Mahdiyeh Hedayati-Moghadam Maryam Paseban Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats Future Natural Products vitamin c propylthiouracil hypothyroidism cardiovascular oxidative stress |
| title | Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats |
| title_full | Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats |
| title_fullStr | Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats |
| title_full_unstemmed | Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats |
| title_short | Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats |
| title_sort | effects of vitamin c on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats |
| topic | vitamin c propylthiouracil hypothyroidism cardiovascular oxidative stress |
| url | http://fnp.skums.ac.ir/Article/fnp-183 |
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