Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats
Background and aims: Hypothyroidism and cardiovascular diseases are associated with oxidative stress. Vitamin C is widely recognized for its antioxidant properties. This study aimed to investigate the effects of vitamin C during the neonatal and juvenile periods on oxidative stress induced by hyp...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2024-12-01
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| Series: | Future Natural Products |
| Subjects: | |
| Online Access: | http://fnp.skums.ac.ir/Article/fnp-183 |
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| Summary: | Background and aims: Hypothyroidism and cardiovascular diseases are associated with
oxidative stress. Vitamin C is widely recognized for its antioxidant properties. This study aimed
to investigate the effects of vitamin C during the neonatal and juvenile periods on oxidative stress
induced by hypothyroidism in the hearts of rats.
Methods: Sixteen pregnant rats were randomly divided into five groups after delivery: a control
group, a group receiving propylthiouracil (PTU), and three treatment groups receiving PTU
along with 10, 100, and 500 mg/kg of vitamin C. The experimental treatments continued for
the first eight weeks of the offspring’s life, following the lactation period, and the offspring were
treated in the same manner. At the end of the study, the rats were sacrificed, and serum, aortic,
and cardiac tissues were collected for antioxidant evaluation.
Results: In the group receiving PTU, levels of thyroxine and antioxidant enzymes were decreased
in serum, heart, and aortic tissues. In contrast, the groups receiving PTU along with various
doses of vitamin C demonstrated an attenuation of these parameters.
Conclusion: Based on the findings, vitamin C supplementation improved cardiovascular
oxidative stress induced by hypothyroidism in rats. |
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| ISSN: | 2783-4662 |