Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China
Abstract HIV-associated diffuse large B-cell lymphoma (DLBCL) is a rare type of lymphoma with poor prognosis. β2-microglobulin (β2-M) is elevated in people living with HIV, but its prognostic significance in HIV-associated DLBCL remains unclear. We retrospectively analyzed 89 HIV-associated DLBCL pa...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-99888-8 |
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| author | Xinyi Tang Tingting Jiang Bingling Guo Jun Liu Chaoyu Wang Yakun Zhang Shuang Chen Yu Peng Xiaomei Zhang Jun Li Yao Liu Zailin Yang |
| author_facet | Xinyi Tang Tingting Jiang Bingling Guo Jun Liu Chaoyu Wang Yakun Zhang Shuang Chen Yu Peng Xiaomei Zhang Jun Li Yao Liu Zailin Yang |
| author_sort | Xinyi Tang |
| collection | DOAJ |
| description | Abstract HIV-associated diffuse large B-cell lymphoma (DLBCL) is a rare type of lymphoma with poor prognosis. β2-microglobulin (β2-M) is elevated in people living with HIV, but its prognostic significance in HIV-associated DLBCL remains unclear. We retrospectively analyzed 89 HIV-associated DLBCL patients treated at Chongqing University Cancer Hospital between October 2012 and December 2023. The primary outcome was the clinical overall survival (OS) rate. The optimal cut-off value of β2-M was determined to be 5 mg/L. Compared to the low serum β2-M group (< 5 mg/L), patients in the high serum β2-M group (≥ 5 mg/L) had a higher International Prognostic Index (IPI)/ age adjusted IPI (aaIPI) score, more B symptoms, lower CD4+T cell counts, and higher lactate dehydrogenase (LDH) level. Patients in high group exhibited poorer OS, with 1-, 3-, and 5-year OS rates of 33.4%, 22.8%, and 18.2%, respectively. Multivariate Cox regression analysis identified serum β2-M ≥ 5 mg/L as an independent risk factor influencing OS of this patient group. Moreover, CD8+T cell count < 392 cells/µL, LDH ≥ 375 U/L, and non-receipt of standard treatment were also independent risk factors. Receiver operating characteristic curve analysis demonstrated that these four independent risk factors accurately predicted survival in HIV-associated DLBCL. 5 mg/L threshold for serum β2-M was associated with poor OS in HIV-associated DLBCL, indicating it could serve as a novel biomarker for assessing their prognosis. |
| format | Article |
| id | doaj-art-86c9ed21bbed48568114f1067db7b6f3 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-86c9ed21bbed48568114f1067db7b6f32025-08-20T03:09:35ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-99888-8Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from ChinaXinyi Tang0Tingting Jiang1Bingling Guo2Jun Liu3Chaoyu Wang4Yakun Zhang5Shuang Chen6Yu Peng7Xiaomei Zhang8Jun Li9Yao Liu10Zailin Yang11School of Medicine, Chongqing UniversityDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalSchool of Medicine, Chongqing UniversityDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalDepartment of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer HospitalAbstract HIV-associated diffuse large B-cell lymphoma (DLBCL) is a rare type of lymphoma with poor prognosis. β2-microglobulin (β2-M) is elevated in people living with HIV, but its prognostic significance in HIV-associated DLBCL remains unclear. We retrospectively analyzed 89 HIV-associated DLBCL patients treated at Chongqing University Cancer Hospital between October 2012 and December 2023. The primary outcome was the clinical overall survival (OS) rate. The optimal cut-off value of β2-M was determined to be 5 mg/L. Compared to the low serum β2-M group (< 5 mg/L), patients in the high serum β2-M group (≥ 5 mg/L) had a higher International Prognostic Index (IPI)/ age adjusted IPI (aaIPI) score, more B symptoms, lower CD4+T cell counts, and higher lactate dehydrogenase (LDH) level. Patients in high group exhibited poorer OS, with 1-, 3-, and 5-year OS rates of 33.4%, 22.8%, and 18.2%, respectively. Multivariate Cox regression analysis identified serum β2-M ≥ 5 mg/L as an independent risk factor influencing OS of this patient group. Moreover, CD8+T cell count < 392 cells/µL, LDH ≥ 375 U/L, and non-receipt of standard treatment were also independent risk factors. Receiver operating characteristic curve analysis demonstrated that these four independent risk factors accurately predicted survival in HIV-associated DLBCL. 5 mg/L threshold for serum β2-M was associated with poor OS in HIV-associated DLBCL, indicating it could serve as a novel biomarker for assessing their prognosis.https://doi.org/10.1038/s41598-025-99888-8β2-MHIVDLBCLOverall survival |
| spellingShingle | Xinyi Tang Tingting Jiang Bingling Guo Jun Liu Chaoyu Wang Yakun Zhang Shuang Chen Yu Peng Xiaomei Zhang Jun Li Yao Liu Zailin Yang Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China Scientific Reports β2-M HIV DLBCL Overall survival |
| title | Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China |
| title_full | Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China |
| title_fullStr | Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China |
| title_full_unstemmed | Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China |
| title_short | Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China |
| title_sort | serum β2 microglobulin level is associated with the survival of hiv associated diffuse large b cell lymphoma a retrospective study from china |
| topic | β2-M HIV DLBCL Overall survival |
| url | https://doi.org/10.1038/s41598-025-99888-8 |
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