Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia
A 41-year-old man presented with nonspecific complaints of nausea, vomiting, and generalized fatigue for 2 months. He had renal dysfunction and severe anemia, for which he underwent acute peritoneal dialysis and four packed red blood cell transfusions at another hospital. Sampling his blood for labo...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Kidney Diseases |
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| Online Access: | https://journals.lww.com/10.4103/ijkd.ijkd_15_23 |
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| author | Mohammed Fahad Khan Ravi Jangamani Mahesha Vankalakunti H. Sudarshan Ballal |
| author_facet | Mohammed Fahad Khan Ravi Jangamani Mahesha Vankalakunti H. Sudarshan Ballal |
| author_sort | Mohammed Fahad Khan |
| collection | DOAJ |
| description | A 41-year-old man presented with nonspecific complaints of nausea, vomiting, and generalized fatigue for 2 months. He had renal dysfunction and severe anemia, for which he underwent acute peritoneal dialysis and four packed red blood cell transfusions at another hospital. Sampling his blood for laboratory evaluation was difficult as the sample would repeatedly clot before the machine could assess the same. It was found that the patient had hyperproteinemia, with hyperviscosity which was causing the same. Further evaluation revealed a monoclonal gammopathy, which was IgM predominant, and bone marrow evaluation revealed Waldenstrom’s macroglobulinemia (WM). Renal biopsy also showed light-chain cast nephropathy. The patient underwent three sessions of plasmapheresis and was initiated on chemotherapy and showed symptomatic and laboratory improvement. This case reveals renal involvement in WM, which is rare and highlights the difficulty faced in evaluating the plasma samples of the patient for laboratory investigations. |
| format | Article |
| id | doaj-art-86c684ad08dd4f8090ee97121a359606 |
| institution | OA Journals |
| issn | 2950-0761 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Kidney Diseases |
| spelling | doaj-art-86c684ad08dd4f8090ee97121a3596062025-08-20T02:05:17ZengWolters Kluwer Medknow PublicationsIndian Journal of Kidney Diseases2950-07612023-01-0121283110.4103/ijkd.ijkd_15_23Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s MacroglobulinemiaMohammed Fahad KhanRavi JangamaniMahesha VankalakuntiH. Sudarshan BallalA 41-year-old man presented with nonspecific complaints of nausea, vomiting, and generalized fatigue for 2 months. He had renal dysfunction and severe anemia, for which he underwent acute peritoneal dialysis and four packed red blood cell transfusions at another hospital. Sampling his blood for laboratory evaluation was difficult as the sample would repeatedly clot before the machine could assess the same. It was found that the patient had hyperproteinemia, with hyperviscosity which was causing the same. Further evaluation revealed a monoclonal gammopathy, which was IgM predominant, and bone marrow evaluation revealed Waldenstrom’s macroglobulinemia (WM). Renal biopsy also showed light-chain cast nephropathy. The patient underwent three sessions of plasmapheresis and was initiated on chemotherapy and showed symptomatic and laboratory improvement. This case reveals renal involvement in WM, which is rare and highlights the difficulty faced in evaluating the plasma samples of the patient for laboratory investigations.https://journals.lww.com/10.4103/ijkd.ijkd_15_23cast nephropathyhyperviscositywaldenstrom’s macroglobulinemia |
| spellingShingle | Mohammed Fahad Khan Ravi Jangamani Mahesha Vankalakunti H. Sudarshan Ballal Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia Indian Journal of Kidney Diseases cast nephropathy hyperviscosity waldenstrom’s macroglobulinemia |
| title | Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia |
| title_full | Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia |
| title_fullStr | Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia |
| title_full_unstemmed | Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia |
| title_short | Blood is Always Thicker than Water – A Case of Renal Involvement in Waldenstrom’s Macroglobulinemia |
| title_sort | blood is always thicker than water a case of renal involvement in waldenstrom s macroglobulinemia |
| topic | cast nephropathy hyperviscosity waldenstrom’s macroglobulinemia |
| url | https://journals.lww.com/10.4103/ijkd.ijkd_15_23 |
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