HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway

HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway

Abstract Background Inflammation and proinflammatory programmed cell death, referred to as pyroptosis, are important causes of poor functional recovery after traumatic spinal cord injury (TSCI). Heat shock protein family A member 1A (HSPA1A) is a molecular chaperone protein that is highly expressed...

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Bibliographic Details
Main Authors: Xuegang He, Bo Deng, Cangyu Zhang, Guangzhi Zhang, Fengguang Yang, Daxue Zhu, Yong Yang, Bing Ma, Xuchang Hu, Yonggang Wang, Xuewen Kang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
Traumatic spinal cord injury
HSPA1A
DUSP1
Pyroptosis
Inflammation
Online Access:https://doi.org/10.1186/s10020-025-01086-9
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