Angiogenic Factors and Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation and impaired epithelial barrier function. Emerging evidence highlights the critical role of vascular remodeling and angiogenesis in IBD pathogenesis. This review ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/5/1154 |
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| author | Zhiru Li Li Zeng Wei Huang Xinxing Zhang Li Zhang Qin Xie |
| author_facet | Zhiru Li Li Zeng Wei Huang Xinxing Zhang Li Zhang Qin Xie |
| author_sort | Zhiru Li |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation and impaired epithelial barrier function. Emerging evidence highlights the critical role of vascular remodeling and angiogenesis in IBD pathogenesis. This review explores the intricate relationship between blood vessels and the intestinal epithelial barrier, emphasizing how aberrant vascularization contributes to barrier dysfunction and disease progression. In IBD, excessive angiogenesis is driven by hypoxia, immune cell infiltration, and pro-inflammatory cytokines, further perpetuating inflammation and tissue damage. Key angiogenic factors, such as vascular endothelial growth factor (VEGF), angiopoietins, and platelet-derived growth factor (PDGF), are upregulated in IBD, promoting pathological vessel formation. These newly formed vessels are often immature and hyperpermeable, exacerbating leukocyte recruitment and inflammatory responses. Given the pivotal role of angiogenesis in IBD, anti-angiogenic therapies have emerged as a potential therapeutic strategy. Preclinical and clinical studies targeting VEGF and other angiogenic pathways have shown promise in reducing inflammation and promoting mucosal healing. This review summarizes current knowledge on vascular–epithelial interactions in IBD, the mechanisms driving pathological angiogenesis, and the therapeutic potential of anti-angiogenic approaches, providing insights for future research and treatment development. |
| format | Article |
| id | doaj-art-86bc8470b6304e55b63f1febe36cb73f |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-86bc8470b6304e55b63f1febe36cb73f2025-08-20T03:47:48ZengMDPI AGBiomedicines2227-90592025-05-01135115410.3390/biomedicines13051154Angiogenic Factors and Inflammatory Bowel DiseasesZhiru Li0Li Zeng1Wei Huang2Xinxing Zhang3Li Zhang4Qin Xie5Clinical Medical School, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Geriatric Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Geriatric Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Geriatric Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Geriatric Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Geriatric Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaInflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation and impaired epithelial barrier function. Emerging evidence highlights the critical role of vascular remodeling and angiogenesis in IBD pathogenesis. This review explores the intricate relationship between blood vessels and the intestinal epithelial barrier, emphasizing how aberrant vascularization contributes to barrier dysfunction and disease progression. In IBD, excessive angiogenesis is driven by hypoxia, immune cell infiltration, and pro-inflammatory cytokines, further perpetuating inflammation and tissue damage. Key angiogenic factors, such as vascular endothelial growth factor (VEGF), angiopoietins, and platelet-derived growth factor (PDGF), are upregulated in IBD, promoting pathological vessel formation. These newly formed vessels are often immature and hyperpermeable, exacerbating leukocyte recruitment and inflammatory responses. Given the pivotal role of angiogenesis in IBD, anti-angiogenic therapies have emerged as a potential therapeutic strategy. Preclinical and clinical studies targeting VEGF and other angiogenic pathways have shown promise in reducing inflammation and promoting mucosal healing. This review summarizes current knowledge on vascular–epithelial interactions in IBD, the mechanisms driving pathological angiogenesis, and the therapeutic potential of anti-angiogenic approaches, providing insights for future research and treatment development.https://www.mdpi.com/2227-9059/13/5/1154inflammatory bowel diseaseangiogenesisangiogenic factors |
| spellingShingle | Zhiru Li Li Zeng Wei Huang Xinxing Zhang Li Zhang Qin Xie Angiogenic Factors and Inflammatory Bowel Diseases Biomedicines inflammatory bowel disease angiogenesis angiogenic factors |
| title | Angiogenic Factors and Inflammatory Bowel Diseases |
| title_full | Angiogenic Factors and Inflammatory Bowel Diseases |
| title_fullStr | Angiogenic Factors and Inflammatory Bowel Diseases |
| title_full_unstemmed | Angiogenic Factors and Inflammatory Bowel Diseases |
| title_short | Angiogenic Factors and Inflammatory Bowel Diseases |
| title_sort | angiogenic factors and inflammatory bowel diseases |
| topic | inflammatory bowel disease angiogenesis angiogenic factors |
| url | https://www.mdpi.com/2227-9059/13/5/1154 |
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