Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment?
The link between inflammation and cancer has been extensively studied over the years. While the inflammatory process can facilitate tumor establishment and progression, on the other hand, current clinical approaches aim to boost the immune system against the tumor mass. In this scenario, the convent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/203 |
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| author | Chiara Colarusso Michela Terlizzi Simone Di Caprio Anna Falanga Emmanuel D’Andria Roberta d’Emmanuele di Villa Bianca Rosalinda Sorrentino |
| author_facet | Chiara Colarusso Michela Terlizzi Simone Di Caprio Anna Falanga Emmanuel D’Andria Roberta d’Emmanuele di Villa Bianca Rosalinda Sorrentino |
| author_sort | Chiara Colarusso |
| collection | DOAJ |
| description | The link between inflammation and cancer has been extensively studied over the years. While the inflammatory process can facilitate tumor establishment and progression, on the other hand, current clinical approaches aim to boost the immune system against the tumor mass. In this scenario, the conventional chemotherapy has proven to induce immunogenic cell death in that the release of danger-associated alarmins can foster the cytotoxic immunity following the blockade of immune checkpoints. The release of alarmins can activate the inflammasome pathway. Thus, one of the questions is as follows: can conventional anti-tumor drugs lead to inflammasome activation? And if so, is the resulting effect anti- or pro-tumor? In this review, we provide an overview on the role of the inflammasome in cancer. |
| format | Article |
| id | doaj-art-86ba8875f246481a863319baa45f9ee3 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-86ba8875f246481a863319baa45f9ee32025-01-24T13:24:23ZengMDPI AGBiomedicines2227-90592025-01-0113120310.3390/biomedicines13010203Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment?Chiara Colarusso0Michela Terlizzi1Simone Di Caprio2Anna Falanga3Emmanuel D’Andria4Roberta d’Emmanuele di Villa Bianca5Rosalinda Sorrentino6Department of Pharmacy (DIFARMA), University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy (DIFARMA), University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy (DIFARMA), University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy (DIFARMA), University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy (DIFARMA), University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, NA, ItalyDepartment of Pharmacy (DIFARMA), University of Salerno, 84084 Fisciano, SA, ItalyThe link between inflammation and cancer has been extensively studied over the years. While the inflammatory process can facilitate tumor establishment and progression, on the other hand, current clinical approaches aim to boost the immune system against the tumor mass. In this scenario, the conventional chemotherapy has proven to induce immunogenic cell death in that the release of danger-associated alarmins can foster the cytotoxic immunity following the blockade of immune checkpoints. The release of alarmins can activate the inflammasome pathway. Thus, one of the questions is as follows: can conventional anti-tumor drugs lead to inflammasome activation? And if so, is the resulting effect anti- or pro-tumor? In this review, we provide an overview on the role of the inflammasome in cancer.https://www.mdpi.com/2227-9059/13/1/203cancerchemotherapyinflammasomeimmunogenic-cell death (ICD)inflammation |
| spellingShingle | Chiara Colarusso Michela Terlizzi Simone Di Caprio Anna Falanga Emmanuel D’Andria Roberta d’Emmanuele di Villa Bianca Rosalinda Sorrentino Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? Biomedicines cancer chemotherapy inflammasome immunogenic-cell death (ICD) inflammation |
| title | Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? |
| title_full | Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? |
| title_fullStr | Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? |
| title_full_unstemmed | Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? |
| title_short | Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? |
| title_sort | conventional chemotherapy and inflammation what is the role of the inflammasome in the tumor microenvironment |
| topic | cancer chemotherapy inflammasome immunogenic-cell death (ICD) inflammation |
| url | https://www.mdpi.com/2227-9059/13/1/203 |
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