Mitochondrial DNA in atherosclerosis research progress: a mini review
Atherosclerosis (AS) is a chronic inflammatory disease that primarily affects large and medium-sized arteries and is one of the leading causes of death worldwide. This article reviews the multifaceted role of mitochondrial DNA (mtDNA) in AS, including its structure, function, release, and relationsh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526390/full |
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| _version_ | 1825206727542308864 |
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| author | Zheng Liu Nan Huang Chan Liu Can Wu Ling Zhou Xiang Liu Haibo Lei |
| author_facet | Zheng Liu Nan Huang Chan Liu Can Wu Ling Zhou Xiang Liu Haibo Lei |
| author_sort | Zheng Liu |
| collection | DOAJ |
| description | Atherosclerosis (AS) is a chronic inflammatory disease that primarily affects large and medium-sized arteries and is one of the leading causes of death worldwide. This article reviews the multifaceted role of mitochondrial DNA (mtDNA) in AS, including its structure, function, release, and relationship with inflammation. Damage and release of mtDNA are considered central drivers in the development of AS, as they participate in the progression of AS by activating inflammatory pathways and affecting lipid metabolism. Therefore, therapeutic strategies targeting mtDNA and its downstream effects may provide new avenues to address this global health challenge. |
| format | Article |
| id | doaj-art-86b99a94bd1146e081d807251d911910 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-86b99a94bd1146e081d807251d9119102025-02-07T06:49:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15263901526390Mitochondrial DNA in atherosclerosis research progress: a mini reviewZheng Liu0Nan Huang1Chan Liu2Can Wu3Ling Zhou4Xiang Liu5Haibo Lei6Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, ChinaDepartment of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, ChinaDepartment of Clinical Pharmacy, Liuyang People’s Hospital, Liuyang, ChinaDepartment of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, ChinaDepartment of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, ChinaDepartment of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, ChinaDepartment of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, ChinaAtherosclerosis (AS) is a chronic inflammatory disease that primarily affects large and medium-sized arteries and is one of the leading causes of death worldwide. This article reviews the multifaceted role of mitochondrial DNA (mtDNA) in AS, including its structure, function, release, and relationship with inflammation. Damage and release of mtDNA are considered central drivers in the development of AS, as they participate in the progression of AS by activating inflammatory pathways and affecting lipid metabolism. Therefore, therapeutic strategies targeting mtDNA and its downstream effects may provide new avenues to address this global health challenge.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526390/fullmtDNAatherosclerosismitochondriainflammationresearch progress |
| spellingShingle | Zheng Liu Nan Huang Chan Liu Can Wu Ling Zhou Xiang Liu Haibo Lei Mitochondrial DNA in atherosclerosis research progress: a mini review Frontiers in Immunology mtDNA atherosclerosis mitochondria inflammation research progress |
| title | Mitochondrial DNA in atherosclerosis research progress: a mini review |
| title_full | Mitochondrial DNA in atherosclerosis research progress: a mini review |
| title_fullStr | Mitochondrial DNA in atherosclerosis research progress: a mini review |
| title_full_unstemmed | Mitochondrial DNA in atherosclerosis research progress: a mini review |
| title_short | Mitochondrial DNA in atherosclerosis research progress: a mini review |
| title_sort | mitochondrial dna in atherosclerosis research progress a mini review |
| topic | mtDNA atherosclerosis mitochondria inflammation research progress |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526390/full |
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