Lupus nephritis and thrombotic microangiopathy: A review
Lupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology. One of...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2024-01-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/634100/149189 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850038776849498112 |
|---|---|
| author | Larisa A. Bobrova Natalia L. Kozlovskaya |
| author_facet | Larisa A. Bobrova Natalia L. Kozlovskaya |
| author_sort | Larisa A. Bobrova |
| collection | DOAJ |
| description | Lupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology. One of the variants of renal microvascular injury is thrombotic microangiopathy (TMA), the mechanisms of which are diverse. The review focuses on the main forms of TMA, including antiphospholipid syndrome and nephropathy associated with antiphospholipid syndrome, TMA caused by complement system regulation disorders and deficiency of ADAMTS13. In most cases, these forms of TMA are combined with LN. However, they may also exist as a single form of kidney damage. This article discusses the TMA pathogenesis, the impact on kidney prognosis, and treatment options. |
| format | Article |
| id | doaj-art-86b817fb0953449e98033b58d3e7f142 |
| institution | DOAJ |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj-art-86b817fb0953449e98033b58d3e7f1422025-08-20T02:56:30Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422024-01-0196662863410.26442/00403660.2024.06.20273178517Lupus nephritis and thrombotic microangiopathy: A reviewLarisa A. Bobrova0https://orcid.org/0000-0001-6265-4091Natalia L. Kozlovskaya1https://orcid.org/0000-0002-4275-0315Sechenov First Moscow State Medical University (Sechenov University)Patrice Lumumba People’s Friendship University of RussiaLupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology. One of the variants of renal microvascular injury is thrombotic microangiopathy (TMA), the mechanisms of which are diverse. The review focuses on the main forms of TMA, including antiphospholipid syndrome and nephropathy associated with antiphospholipid syndrome, TMA caused by complement system regulation disorders and deficiency of ADAMTS13. In most cases, these forms of TMA are combined with LN. However, they may also exist as a single form of kidney damage. This article discusses the TMA pathogenesis, the impact on kidney prognosis, and treatment options.https://ter-arkhiv.ru/0040-3660/article/viewFile/634100/149189lupus nephritisthrombotic microangiopathy |
| spellingShingle | Larisa A. Bobrova Natalia L. Kozlovskaya Lupus nephritis and thrombotic microangiopathy: A review Терапевтический архив lupus nephritis thrombotic microangiopathy |
| title | Lupus nephritis and thrombotic microangiopathy: A review |
| title_full | Lupus nephritis and thrombotic microangiopathy: A review |
| title_fullStr | Lupus nephritis and thrombotic microangiopathy: A review |
| title_full_unstemmed | Lupus nephritis and thrombotic microangiopathy: A review |
| title_short | Lupus nephritis and thrombotic microangiopathy: A review |
| title_sort | lupus nephritis and thrombotic microangiopathy a review |
| topic | lupus nephritis thrombotic microangiopathy |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/634100/149189 |
| work_keys_str_mv | AT larisaabobrova lupusnephritisandthromboticmicroangiopathyareview AT natalialkozlovskaya lupusnephritisandthromboticmicroangiopathyareview |