C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients
While some biomolecules have been explored to identify potential biomarkers for the prognosis of COVID-19 patients, there is no reliable prognostic indicator of the disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection outcom...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2021/5557582 |
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| author | Mahmoud Sadeghi-Haddad-Zavareh Masomeh Bayani Mehran Shokri Soheil Ebrahimpour Arefeh Babazadeh Rahele Mehraeen Emadoddin Moudi Ali Rostami Mohammad Barary Akram Hosseini Ali Bijani Mostafa Javanian |
| author_facet | Mahmoud Sadeghi-Haddad-Zavareh Masomeh Bayani Mehran Shokri Soheil Ebrahimpour Arefeh Babazadeh Rahele Mehraeen Emadoddin Moudi Ali Rostami Mohammad Barary Akram Hosseini Ali Bijani Mostafa Javanian |
| author_sort | Mahmoud Sadeghi-Haddad-Zavareh |
| collection | DOAJ |
| description | While some biomolecules have been explored to identify potential biomarkers for the prognosis of COVID-19 patients, there is no reliable prognostic indicator of the disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection outcome. This retrospective study was conducted on 429 patients diagnosed with COVID-19 between March 30, 2020, and April 30, 2020. The study population was divided into severe (n = 175) and nonsevere cases (n = 254). Data on demographic characteristics, clinical features, and laboratory findings on admission were collected. The proportion of patients with increased CRP levels was significantly higher in severe cases than in nonsevere patients. Analysis of the receiver operating characteristic (ROC) curve found that CRP could be used as an independent factor in predicting the severity of COVID-19. Also, patients with CRP >64.75 mg/L were more likely to have severe complications. In conclusion, CRP serum levels can predict the severity and progression of illness in patients with COVID-19. |
| format | Article |
| id | doaj-art-86b210b03cbf4cbeb74937a5f9b3232e |
| institution | OA Journals |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-86b210b03cbf4cbeb74937a5f9b3232e2025-08-20T02:08:34ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982021-01-01202110.1155/2021/55575825557582C-Reactive Protein as a Prognostic Indicator in COVID-19 PatientsMahmoud Sadeghi-Haddad-Zavareh0Masomeh Bayani1Mehran Shokri2Soheil Ebrahimpour3Arefeh Babazadeh4Rahele Mehraeen5Emadoddin Moudi6Ali Rostami7Mohammad Barary8Akram Hosseini9Ali Bijani10Mostafa Javanian11Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Radiology, School of Medicine, Babol University of Medical Sciences, Babol, IranClinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, IranInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranStudent Research Committee, Babol University of Medical Sciences, Babol, IranDepartment of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranWhile some biomolecules have been explored to identify potential biomarkers for the prognosis of COVID-19 patients, there is no reliable prognostic indicator of the disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection outcome. This retrospective study was conducted on 429 patients diagnosed with COVID-19 between March 30, 2020, and April 30, 2020. The study population was divided into severe (n = 175) and nonsevere cases (n = 254). Data on demographic characteristics, clinical features, and laboratory findings on admission were collected. The proportion of patients with increased CRP levels was significantly higher in severe cases than in nonsevere patients. Analysis of the receiver operating characteristic (ROC) curve found that CRP could be used as an independent factor in predicting the severity of COVID-19. Also, patients with CRP >64.75 mg/L were more likely to have severe complications. In conclusion, CRP serum levels can predict the severity and progression of illness in patients with COVID-19.http://dx.doi.org/10.1155/2021/5557582 |
| spellingShingle | Mahmoud Sadeghi-Haddad-Zavareh Masomeh Bayani Mehran Shokri Soheil Ebrahimpour Arefeh Babazadeh Rahele Mehraeen Emadoddin Moudi Ali Rostami Mohammad Barary Akram Hosseini Ali Bijani Mostafa Javanian C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients Interdisciplinary Perspectives on Infectious Diseases |
| title | C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients |
| title_full | C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients |
| title_fullStr | C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients |
| title_full_unstemmed | C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients |
| title_short | C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients |
| title_sort | c reactive protein as a prognostic indicator in covid 19 patients |
| url | http://dx.doi.org/10.1155/2021/5557582 |
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