Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial

Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial

Background Rheumatoid arthritis elevates cardiovascular disease risk. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a regulator of low-density lipoprotein (LDL) metabolism, increases LDL-receptor breakdown in the liver, which elevates LDL-cholesterol levels. In addition, PCSK9 has direct ef...

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Main Authors: Ronald F van Vollenhoven, Merete Lund Hetland, Till Uhlig, Dan Nordström, Jos WR Twisk, Mikkel Østergaard, Michael T Nurmohamed, Bjorn Gudbjornsson, Gerður Gröndal, Johan Frostegård, Kim Hørslev-Petersen, Anna Rudin, Jon Lampa, Kristina Lend, Tuulikki Sokka-Isler, Bas Dijkshoorn, Nupur Kumar
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/11/2/e005129.full
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