Impact of CYP2D6, MAOA, and UGT2B7 genetic variants on recurrence of Plasmodium Vivax in the Brazilian Amazon

Impact of CYP2D6, MAOA, and UGT2B7 genetic variants on recurrence of Plasmodium Vivax in the Brazilian Amazon

Abstract The biotransformation of primaquine is mediated by cytochrome P-450 (CYP) enzymes and monoamine oxygenase A (MAO-A). Polymorphisms in the genes that encode these enzymes can alter the clinical response of patients with Plasmodium vivax malaria, leading to therapeutic failure and recurrences...

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Main Authors: Gabrielly S. da Silva, Flávia A. Fontenelle, Amanda O. Carvalho, Marielle M. Macêdo, Manuela C. Morais, Rebeca L. Abreu Netto, Victor I. Mwangi, Maria G. C. Alecrim, Marcus V. G. Lacerda, Fernanda Rodrigues-Soares, Anne C. G. de Almeida, Gisely Cardoso de Melo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Plasmodium vivax
Recurrences
Primaquine
CYP2D6
MAOA
UGT2B7
Online Access:https://doi.org/10.1038/s41598-025-94679-7
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