Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex
Abstract Primates excel at mapping sensory inputs flexibly onto motor outcomes. We asked if the neural dynamics to support context-sensitive sensorimotor mapping generalizes or differs between different behavioral contexts that demand such flexibility. We compared reaching under mirror-reversed visi...
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| Format: | Article |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56360-5 |
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| _version_ | 1823861818324418560 |
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| author | Hao Guo Shenbing Kuang Alexander Gail |
| author_facet | Hao Guo Shenbing Kuang Alexander Gail |
| author_sort | Hao Guo |
| collection | DOAJ |
| description | Abstract Primates excel at mapping sensory inputs flexibly onto motor outcomes. We asked if the neural dynamics to support context-sensitive sensorimotor mapping generalizes or differs between different behavioral contexts that demand such flexibility. We compared reaching under mirror-reversed vision, a case of adaptation to a modified sensorimotor environment (SE), with anti reaching, a case of applying an abstract task rule (TR). While neural dynamics in monkey posterior parietal cortex show shifted initial states and non-aligned low-dimensional neural subspaces in the SE task, remapping is achieved in overlapping subspaces in the TR task. A recurrent neural network model demonstrates how output constraints mimicking SE and TR tasks are sufficient to generate the two fundamentally different neural computational dynamics. We conclude that sensorimotor remapping to implement an abstract task rule happens within the existing repertoire of neural dynamics, while compensation of perturbed sensory feedback requires exploration of independent neural dynamics in parietal cortex. |
| format | Article |
| id | doaj-art-86ace2cf718243c59f0bac07ca08ab6c |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-86ace2cf718243c59f0bac07ca08ab6c2025-02-09T12:46:27ZengNature PortfolioNature Communications2041-17232025-02-0116111710.1038/s41467-025-56360-5Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortexHao Guo0Shenbing Kuang1Alexander Gail2German Primate CenterState Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of SciencesGerman Primate CenterAbstract Primates excel at mapping sensory inputs flexibly onto motor outcomes. We asked if the neural dynamics to support context-sensitive sensorimotor mapping generalizes or differs between different behavioral contexts that demand such flexibility. We compared reaching under mirror-reversed vision, a case of adaptation to a modified sensorimotor environment (SE), with anti reaching, a case of applying an abstract task rule (TR). While neural dynamics in monkey posterior parietal cortex show shifted initial states and non-aligned low-dimensional neural subspaces in the SE task, remapping is achieved in overlapping subspaces in the TR task. A recurrent neural network model demonstrates how output constraints mimicking SE and TR tasks are sufficient to generate the two fundamentally different neural computational dynamics. We conclude that sensorimotor remapping to implement an abstract task rule happens within the existing repertoire of neural dynamics, while compensation of perturbed sensory feedback requires exploration of independent neural dynamics in parietal cortex.https://doi.org/10.1038/s41467-025-56360-5 |
| spellingShingle | Hao Guo Shenbing Kuang Alexander Gail Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex Nature Communications |
| title | Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex |
| title_full | Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex |
| title_fullStr | Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex |
| title_full_unstemmed | Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex |
| title_short | Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex |
| title_sort | sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex |
| url | https://doi.org/10.1038/s41467-025-56360-5 |
| work_keys_str_mv | AT haoguo sensorimotorenvironmentbutnottaskrulereconfigurespopulationdynamicsinrhesusmonkeyposteriorparietalcortex AT shenbingkuang sensorimotorenvironmentbutnottaskrulereconfigurespopulationdynamicsinrhesusmonkeyposteriorparietalcortex AT alexandergail sensorimotorenvironmentbutnottaskrulereconfigurespopulationdynamicsinrhesusmonkeyposteriorparietalcortex |