Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity

Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity

Summary: Chronic pain following peripheral nerve injury is accompanied by increased neuronal activity in the somatosensory cortex. However, whether and how cortical microglia contribute to these changes is less understood. To this end, we applied an optogenetic strategy to specifically target cortic...

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Bibliographic Details
Main Authors: Min-Hee Yi, Yi Liu, Yong U. Liu, Jinkyung Lee, Priyanka Hanumaihgari, Sebastian Parusel, Dale B. Bosco, Lingxiao Wang, Jiaying Zheng, Wu Shi, Lattawat Eauchai, Supin Chompoopong, Christine L. Hunt, Long-Jun Wu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004887
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