Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential
Cell-based therapies currently represent the state of art for tissue regenerative treatment approaches for various diseases and disorders. Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, using vectors carrying definite transcription factors, have manifested a breakthro...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/1941629 |
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| _version_ | 1850214786592145408 |
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| author | Israa Ahmed Radwan Dina Rady Marwa M. S. Abbass Sara El Moshy Nermeen AbuBakr Christof E. Dörfer Karim M. Fawzy El-Sayed |
| author_facet | Israa Ahmed Radwan Dina Rady Marwa M. S. Abbass Sara El Moshy Nermeen AbuBakr Christof E. Dörfer Karim M. Fawzy El-Sayed |
| author_sort | Israa Ahmed Radwan |
| collection | DOAJ |
| description | Cell-based therapies currently represent the state of art for tissue regenerative treatment approaches for various diseases and disorders. Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, using vectors carrying definite transcription factors, have manifested a breakthrough in regenerative medicine, relying on their pluripotent nature and ease of generation in large amounts from various dental and nondental tissues. In addition to their potential applications in regenerative medicine and dentistry, iPSCs can also be used in disease modeling and drug testing for personalized medicine. The current review discusses various techniques for the production of iPSC-derived osteogenic and odontogenic progenitors, the therapeutic applications of iPSCs, and their regenerative potential in vivo and in vitro. Through the present review, we aim to explore the potential applications of iPSCs in dental and nondental tissue regeneration and to highlight different protocols used for the generation of different tissues and cell lines from iPSCs. |
| format | Article |
| id | doaj-art-86ab2a078c404302b3c6d7b1d1d720f0 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-86ab2a078c404302b3c6d7b1d1d720f02025-08-20T02:08:47ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/19416291941629Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited PotentialIsraa Ahmed Radwan0Dina Rady1Marwa M. S. Abbass2Sara El Moshy3Nermeen AbuBakr4Christof E. Dörfer5Karim M. Fawzy El-Sayed6Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, GermanyStem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, EgyptCell-based therapies currently represent the state of art for tissue regenerative treatment approaches for various diseases and disorders. Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, using vectors carrying definite transcription factors, have manifested a breakthrough in regenerative medicine, relying on their pluripotent nature and ease of generation in large amounts from various dental and nondental tissues. In addition to their potential applications in regenerative medicine and dentistry, iPSCs can also be used in disease modeling and drug testing for personalized medicine. The current review discusses various techniques for the production of iPSC-derived osteogenic and odontogenic progenitors, the therapeutic applications of iPSCs, and their regenerative potential in vivo and in vitro. Through the present review, we aim to explore the potential applications of iPSCs in dental and nondental tissue regeneration and to highlight different protocols used for the generation of different tissues and cell lines from iPSCs.http://dx.doi.org/10.1155/2020/1941629 |
| spellingShingle | Israa Ahmed Radwan Dina Rady Marwa M. S. Abbass Sara El Moshy Nermeen AbuBakr Christof E. Dörfer Karim M. Fawzy El-Sayed Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential Stem Cells International |
| title | Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential |
| title_full | Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential |
| title_fullStr | Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential |
| title_full_unstemmed | Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential |
| title_short | Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential |
| title_sort | induced pluripotent stem cells in dental and nondental tissue regeneration a review of an unexploited potential |
| url | http://dx.doi.org/10.1155/2020/1941629 |
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