SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts
Abstract Mammalian genomes are subdivided into euchromatic A compartments that contain mostly active chromatin, and inactive, heterochromatic B compartments. However, it is not well understood how A and B genome compartments are established and maintained. Here we study SMCHD1, an SMC-like protein b...
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| Main Authors: | Zhijun Huang, Wei Cui, Ishara Ratnayake, Kristin L. Gallik, Lorna Cohen, Rabi Tawil, Gerd P. Pfeifer |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62211-0 |
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