Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii

Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii

IntroductionAntimicrobial-resistant pathogens are an ongoing threat to human and animal health. According to the World Health Organization (WHO), colistin is considered the last resort antibiotic against human infections due to multidrug-resistant Gram-negative organisms—including Acinetobacter baum...

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Bibliographic Details
Main Authors: Maria Romano, Federico Falchi, Eliana De Gregorio, Maria Stabile, Antonella Migliaccio, Alessia Ruggiero, Valeria Napolitano, Ida Autiero, Flavia Squeglia, Rita Berisio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Microbiology
Subjects:
protein structure
colistin resistance
virtual screening
pEtN transferase
cell wall
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1501051/full
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