Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation

Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation

Abstract The rise of microplastic (MPs) pollution presents a pressing environmental issue, raising concerns about its potential health impacts on human populations. Given the critical role of the liver in detoxification and metabolism, understanding the effects of MPs on the human hepatoma cell line...

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Main Authors: Hana Najahi, Nicola Alessio, Massimo Venditti, Ida Lettiero, Domenico Aprile, Gea Oliveri Conti, Tiziana Cappello, Giovanni Di Bernardo, Umberto Galderisi, Sergio Minucci, Margherita Ferrante, Mohamed Banni
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Particle and Fibre Toxicology
Subjects:
Bafilomycin A1
PET
PE
Hepatocellular carcinoma cell line
Macroautophagy
Mitophagy
Online Access:https://doi.org/10.1186/s12989-025-00632-x
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