Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections
Background: Drug resistance is a major problem in Escherichia coli isolated from surgical wound infections. In this study, we evaluated relationship between phylogenicity and drug resistance. Methodology: A total of 29 multi-drug resistant (MDR) E. coli isolates of known drug resistance genes and...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2009-10-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/66 |
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| author | Muhammad Azeem Saeed Abdul Haque Aamir Ali Mashkoor Mohsin Saira Bashir Ayesha Tariq Amna Afzal Tayyaba Iftikhar Yasra Sarwar |
| author_facet | Muhammad Azeem Saeed Abdul Haque Aamir Ali Mashkoor Mohsin Saira Bashir Ayesha Tariq Amna Afzal Tayyaba Iftikhar Yasra Sarwar |
| author_sort | Muhammad Azeem Saeed |
| collection | DOAJ |
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Background: Drug resistance is a major problem in Escherichia coli isolated from surgical wound infections. In this study, we evaluated relationship between phylogenicity and drug resistance.
Methodology: A total of 29 multi-drug resistant (MDR) E. coli isolates of known drug resistance genes and integron profile were selected for the present study. Triplex PCR was conducted for phylogenetic classification of these isolates into four established phylogenetic groups: A, B1, B2 and D. Statistical analysis was done to determine the association of different drug resistance genes and integrons with the phylogenetic groups.
Results: Most of the isolates (44.8%) belonged to phylogenetic group A followed by group B2 and D (24.1% each) and group B1 (6.9%).
Conclusions: There is a definitive relationship between drug resistance and various phylogenetic groups of E. coli infecting wounds. A shift towards phylogenetic group A might be observed with an increasing drug resistance profile.
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| format | Article |
| id | doaj-art-86985c48ea204efaaa61868577e1eba0 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-10-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-86985c48ea204efaaa61868577e1eba02025-08-20T02:14:22ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-10-0130910.3855/jidc.66Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infectionsMuhammad Azeem Saeed0Abdul Haque1Aamir Ali2Mashkoor Mohsin3Saira Bashir4Ayesha Tariq5Amna Afzal6Tayyaba Iftikhar7Yasra Sarwar8Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, FaisalabadHealth Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PO Box 577, Jhang Road, Faisalabad Background: Drug resistance is a major problem in Escherichia coli isolated from surgical wound infections. In this study, we evaluated relationship between phylogenicity and drug resistance. Methodology: A total of 29 multi-drug resistant (MDR) E. coli isolates of known drug resistance genes and integron profile were selected for the present study. Triplex PCR was conducted for phylogenetic classification of these isolates into four established phylogenetic groups: A, B1, B2 and D. Statistical analysis was done to determine the association of different drug resistance genes and integrons with the phylogenetic groups. Results: Most of the isolates (44.8%) belonged to phylogenetic group A followed by group B2 and D (24.1% each) and group B1 (6.9%). Conclusions: There is a definitive relationship between drug resistance and various phylogenetic groups of E. coli infecting wounds. A shift towards phylogenetic group A might be observed with an increasing drug resistance profile. https://jidc.org/index.php/journal/article/view/66Drug resistanceE. coliwoundsphylogenetic groups |
| spellingShingle | Muhammad Azeem Saeed Abdul Haque Aamir Ali Mashkoor Mohsin Saira Bashir Ayesha Tariq Amna Afzal Tayyaba Iftikhar Yasra Sarwar Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections Journal of Infection in Developing Countries Drug resistance E. coli wounds phylogenetic groups |
| title | Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections |
| title_full | Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections |
| title_fullStr | Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections |
| title_full_unstemmed | Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections |
| title_short | Relationship of drug resistance to phylogenetic groups of E. coli isolates from wound infections |
| title_sort | relationship of drug resistance to phylogenetic groups of e coli isolates from wound infections |
| topic | Drug resistance E. coli wounds phylogenetic groups |
| url | https://jidc.org/index.php/journal/article/view/66 |
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