Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016
Aim of investigation. To determine antimicrobial susceptibility of H. pylori in Smolensk in 2015-2016. Material and methods. Overall 248 adult patients with positive rapid urease test at the time of gastroscopy were included in the study. Antimicrobial susceptibility testing of H. pylori isolates to...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/93 |
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| author | N. N. Dekhnich N. V. Ivanchik R. S. Kozlov A. V. Alimov A. V. Lukyanova O. A. Nagaeva A. S. Steshits P. G. Bruk |
| author_facet | N. N. Dekhnich N. V. Ivanchik R. S. Kozlov A. V. Alimov A. V. Lukyanova O. A. Nagaeva A. S. Steshits P. G. Bruk |
| author_sort | N. N. Dekhnich |
| collection | DOAJ |
| description | Aim of investigation. To determine antimicrobial susceptibility of H. pylori in Smolensk in 2015-2016. Material and methods. Overall 248 adult patients with positive rapid urease test at the time of gastroscopy were included in the study. Antimicrobial susceptibility testing of H. pylori isolates to clarithromycin, amoxicillin, metronidazole, levofloxacin, rifampicin, tetracycline was performed by the agar dilution method. Results. H. pylori was isolated in 33% (n=82) of patients (24 isolates were nonviable after freezing). The rates of resistance among tested isolates of H. pylori were: 3,5% (2/58) for clarithromycin, 3,5% (2/58) for amoxicillin, 10.3% (6/58) for metronidazole, 27,6% (16/58) for levofloxacin, 8.6% (5/58) for rifampicin. No isolates showed resistance to tetracycline. Among 58 H. pylori isolates 29% (17 isolates) were resistant to one antimicrobial agent, 12,1% (7 isolates) were resistant to two antimicrobial agents. Associated resistance was observed for levofloxacin and metronidazole 3,5% (2 isolates), levofloxacin and rifampicin 5,2% (3 isolates), metronidazole and rifampicin 3,5% (2 isolates). Conclusions. Smolensk is the area of low clarithromycin resistance. So, clarithromycin-containing regimens are recommended for first-line empirical eradication therapy. Use of levofloxacin is questionable in relation to high levels of resistance H. pylori to levofloxacin. Use of rifabutin is questionable in relation to relatively high H. pylori rifampicin resistance rate. |
| format | Article |
| id | doaj-art-86937e14a9bc44fb9fd9d75e0e28ec4e |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-86937e14a9bc44fb9fd9d75e0e28ec4e2025-02-10T16:14:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01266243110.22416/1382-4376-2016-6-24-3193Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016N. N. Dekhnich0N. V. Ivanchik1R. S. Kozlov2A. V. Alimov3A. V. Lukyanova4O. A. Nagaeva5A. S. Steshits6P. G. Bruk7Federal state educational government financed institution higher education «Smolensk State Medical University»Federal state educational government financed institution higher education «Smolensk State Medical University»Federal state educational government financed institution higher education «Smolensk State Medical University»«Clinical Hospital № 1»«Clinical Hospital № 1»«Clinical Hospital № 1»«Smolensk Regional Clinical Hospital»«Smolensk Regional Clinical Hospital»Aim of investigation. To determine antimicrobial susceptibility of H. pylori in Smolensk in 2015-2016. Material and methods. Overall 248 adult patients with positive rapid urease test at the time of gastroscopy were included in the study. Antimicrobial susceptibility testing of H. pylori isolates to clarithromycin, amoxicillin, metronidazole, levofloxacin, rifampicin, tetracycline was performed by the agar dilution method. Results. H. pylori was isolated in 33% (n=82) of patients (24 isolates were nonviable after freezing). The rates of resistance among tested isolates of H. pylori were: 3,5% (2/58) for clarithromycin, 3,5% (2/58) for amoxicillin, 10.3% (6/58) for metronidazole, 27,6% (16/58) for levofloxacin, 8.6% (5/58) for rifampicin. No isolates showed resistance to tetracycline. Among 58 H. pylori isolates 29% (17 isolates) were resistant to one antimicrobial agent, 12,1% (7 isolates) were resistant to two antimicrobial agents. Associated resistance was observed for levofloxacin and metronidazole 3,5% (2 isolates), levofloxacin and rifampicin 5,2% (3 isolates), metronidazole and rifampicin 3,5% (2 isolates). Conclusions. Smolensk is the area of low clarithromycin resistance. So, clarithromycin-containing regimens are recommended for first-line empirical eradication therapy. Use of levofloxacin is questionable in relation to high levels of resistance H. pylori to levofloxacin. Use of rifabutin is questionable in relation to relatively high H. pylori rifampicin resistance rate.https://www.gastro-j.ru/jour/article/view/93helicobacter pyloriрезистентность к антимикробным препаратамкларитромицинметронидазоламоксициллинлевофлоксацин |
| spellingShingle | N. N. Dekhnich N. V. Ivanchik R. S. Kozlov A. V. Alimov A. V. Lukyanova O. A. Nagaeva A. S. Steshits P. G. Bruk Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 Российский журнал гастроэнтерологии, гепатологии, колопроктологии helicobacter pylori резистентность к антимикробным препаратам кларитромицин метронидазол амоксициллин левофлоксацин |
| title | Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 |
| title_full | Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 |
| title_fullStr | Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 |
| title_full_unstemmed | Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 |
| title_short | Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 |
| title_sort | antimicrobial susceptibility of helicobacter pylori isolates in smolensk in 2015 2016 |
| topic | helicobacter pylori резистентность к антимикробным препаратам кларитромицин метронидазол амоксициллин левофлоксацин |
| url | https://www.gastro-j.ru/jour/article/view/93 |
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