Licochalcone A suppresses pancreatic ductal adenocarcinoma progression by targeting eEF2K-mediated pyroptosis

Licochalcone A suppresses pancreatic ductal adenocarcinoma progression by targeting eEF2K-mediated pyroptosis

Pancreatic ductal adenocarcinoma (PDAC), a highly aggressive malignancy with increasing incidence and low survival rates, urgently requires novel therapeutic strategies to overcome the limitations posed by current treatment agents like gemcitabine. Licochalcone A (LHA), a bioactive flavonoid derived...

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Bibliographic Details
Main Authors: Junjie Peng, Hiutung Chan, Wenqing Chen, Ken Kin-Lam Yung, King-Ho Cheung, Zhu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic ductal adenocarcinoma
licochalcone A
pyroptosis
autophagy
eEF2K
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1595686/full
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