Mechanism of Intervertebral Disc Degeneration via the β‐Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice

Mechanism of Intervertebral Disc Degeneration via the β‐Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice

ABSTRACT Introduction Degenerative changes in the intervertebral disc (IVD) are known to be a main cause of low back pain (LBP), oftentimes necessitating interventions that may or may not be successful due to a lack of understanding in the degenerative phenotype and its mechanisms. Understanding the...

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Bibliographic Details
Main Authors: Khaled Aboushaala, Ana Chee, Frank Ko, Jad Alkhudari, Saurav Sumughan, Howard S. An, Dino Samartzis, Chun‐do Oh
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
β‐catenin
back pain
CCL2
disc degeneration
mechanisms
molecular
Online Access:https://doi.org/10.1002/jsp2.70053
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