Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria
Abstract Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation. Here, we used the Delftia tsuruhatensis TC1 strain, that inhibits the development of Plasmodium in mosquitoes, but in the context of Leis...
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Nature Portfolio
2025-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58769-4 |
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| author | Pedro Cecilio Luana A. Rogerio Tiago D. Serafim Kristina Tang Laura Willen Eva Iniguez Claudio Meneses Luis F. Chaves Yue Zhang Luiza dos Santos Felix Wei Huang Melina Garcia Guizzo Pablo Castañeda-Casado Marcelo Jacobs-Lorena Jesus G. Valenzuela Janneth Rodrigues Fabiano Oliveira |
| author_facet | Pedro Cecilio Luana A. Rogerio Tiago D. Serafim Kristina Tang Laura Willen Eva Iniguez Claudio Meneses Luis F. Chaves Yue Zhang Luiza dos Santos Felix Wei Huang Melina Garcia Guizzo Pablo Castañeda-Casado Marcelo Jacobs-Lorena Jesus G. Valenzuela Janneth Rodrigues Fabiano Oliveira |
| author_sort | Pedro Cecilio |
| collection | DOAJ |
| description | Abstract Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation. Here, we used the Delftia tsuruhatensis TC1 strain, that inhibits the development of Plasmodium in mosquitoes, but in the context of Leishmania-infected sand flies. We show that D. tsuruhatensis TC1 colonizes the midgut of Phlebotomus duboscqi sand flies and impacts the development of L. major parasites, independently of the colonization timing. This phenotype is likely an indirect consequence of D. tsuruhatensis colonization, related with the induction of sand fly gut dysbiosis. Importantly, Leishmania-infected, D. tsuruhatensis-fed sand flies are less able to transmit L. major parasites and cause disease in mice. Modelling supports the disruption of disease endemicity in the field, highlighting D. tsuruhatensis as a promising agent for the control of leishmaniasis. |
| format | Article |
| id | doaj-art-868591c7fdac48b18df5f6646b2f3ffd |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-868591c7fdac48b18df5f6646b2f3ffd2025-08-20T01:49:39ZengNature PortfolioNature Communications2041-17232025-05-0116111610.1038/s41467-025-58769-4Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteriaPedro Cecilio0Luana A. Rogerio1Tiago D. Serafim2Kristina Tang3Laura Willen4Eva Iniguez5Claudio Meneses6Luis F. Chaves7Yue Zhang8Luiza dos Santos Felix9Wei Huang10Melina Garcia Guizzo11Pablo Castañeda-Casado12Marcelo Jacobs-Lorena13Jesus G. Valenzuela14Janneth Rodrigues15Fabiano Oliveira16Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Environmental and Occupational Health, School of Public Health-Bloomington, and Department of Geography, Indiana UniversityIntegrated Data Sciences Section (IDSS), Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthShanghai Institute of Immunity and Infection, Chinese Academy of SciencesVector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthGlobal Health Medicines R&D, GSK; Tres CantosDepartment of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public HealthVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthGlobal Health Medicines R&D, GSK; Tres CantosVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National; Institute of Allergy and Infectious Diseases, National Institutes of HealthAbstract Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation. Here, we used the Delftia tsuruhatensis TC1 strain, that inhibits the development of Plasmodium in mosquitoes, but in the context of Leishmania-infected sand flies. We show that D. tsuruhatensis TC1 colonizes the midgut of Phlebotomus duboscqi sand flies and impacts the development of L. major parasites, independently of the colonization timing. This phenotype is likely an indirect consequence of D. tsuruhatensis colonization, related with the induction of sand fly gut dysbiosis. Importantly, Leishmania-infected, D. tsuruhatensis-fed sand flies are less able to transmit L. major parasites and cause disease in mice. Modelling supports the disruption of disease endemicity in the field, highlighting D. tsuruhatensis as a promising agent for the control of leishmaniasis.https://doi.org/10.1038/s41467-025-58769-4 |
| spellingShingle | Pedro Cecilio Luana A. Rogerio Tiago D. Serafim Kristina Tang Laura Willen Eva Iniguez Claudio Meneses Luis F. Chaves Yue Zhang Luiza dos Santos Felix Wei Huang Melina Garcia Guizzo Pablo Castañeda-Casado Marcelo Jacobs-Lorena Jesus G. Valenzuela Janneth Rodrigues Fabiano Oliveira Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria Nature Communications |
| title | Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria |
| title_full | Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria |
| title_fullStr | Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria |
| title_full_unstemmed | Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria |
| title_short | Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria |
| title_sort | leishmania sand fly transmission is disrupted by delftia tsuruhatensis tc1 bacteria |
| url | https://doi.org/10.1038/s41467-025-58769-4 |
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