Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female
Background: Aging is associated with the development of various disorders, including postural imbalance, which increases the risk of falls and related health complications. This study examines changes in static postural balance after a 4-week intervention involving appropriate exercise and an optimi...
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MDPI AG
2025-04-01
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| author | Zuzanna Kornatovská Martin Hill Dobroslava Jandová Milada Krejčí Anna Zwierzchowska |
| author_facet | Zuzanna Kornatovská Martin Hill Dobroslava Jandová Milada Krejčí Anna Zwierzchowska |
| author_sort | Zuzanna Kornatovská |
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| description | Background: Aging is associated with the development of various disorders, including postural imbalance, which increases the risk of falls and related health complications. This study examines changes in static postural balance after a 4-week intervention involving appropriate exercise and an optimized daily regimen. Additionally, it explores the relationship between these changes and the steroidome. Methods: The study was conducted on a clinically homogeneous group of 41 females around their sixth decade, diagnosed with anxiety-depressive syndrome and treated with selective serotonin reuptake inhibitors (SSRIs). Postural balance was assessed using the dual-scales method (DLLL-DSM), which estimates postural imbalance by evaluating differences in the lower limb load in the standing position. Correlations between initial DLLL-DSM values, age, BMI, and the baseline levels of nine serum steroids, as well as post-intervention changes in five steroids, were analyzed using multivariate regression (OPLS model). Results: A significant reduction in lower limb load differences (-ΔDLLL-DSM), indicating improved postural balance, was observed. The -ΔDLLL-DSM strongly correlated with initial DLLL-DSM values, age, BMI, initial levels of nine serum steroids, and post-intervention changes in five steroids (R = 0.892, <i>p</i> < 0.001). Furthermore, initial DLLL-DSM values negatively correlated with adrenal androgen androstenediol sulfate and various sulfated 5α/β-reduced androgen metabolites (R = 0.323, <i>p</i> < 0.05), suggesting that the activity of steroid sulfotransferase (SULT2A1) and C17-hydroxylase-C17,20-lyase (CYP17A1) at the lyase step is negatively associated with postural imbalance in elderly females. Conclusions: The findings suggest that even severe postural imbalance can be effectively and relatively rapidly improved through an appropriate exercise-based intervention and an optimized daily regimen, provided that initial adrenal activity is not significantly impaired. Additionally, the identified associations between steroid levels and postural balance provide new insights into the hormonal mechanisms regulating balance control in older individuals. |
| format | Article |
| id | doaj-art-8682f975774b480dad0ca91b78488e41 |
| institution | OA Journals |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Metabolites |
| spelling | doaj-art-8682f975774b480dad0ca91b78488e412025-08-20T02:18:14ZengMDPI AGMetabolites2218-19892025-04-0115423910.3390/metabo15040239Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly FemaleZuzanna Kornatovská0Martin Hill1Dobroslava Jandová2Milada Krejčí3Anna Zwierzchowska4Department of Education, Faculty of Education, University of South Bohemia in Ceske Budejovice, Jeronymova 10, 37115 Ceske Budejovice, Czech RepublicDepartment of Steroid Hormones and Proteofactors, Institute of Endocrinology, 11694 Prague, Czech RepublicDepartment of Biomedicine, College of Physical Education and Sports PALESTRA, 19700 Prague, Czech RepublicDepartment of Wellness and Nutrition Science, College of Physical Education and Sports PALESTRA, 19700 Prague, Czech RepublicInstitute of Sport Science, Academy of Physical Education in Katowice, ul Mikołowska 72a, 40-066 Katowice, PolandBackground: Aging is associated with the development of various disorders, including postural imbalance, which increases the risk of falls and related health complications. This study examines changes in static postural balance after a 4-week intervention involving appropriate exercise and an optimized daily regimen. Additionally, it explores the relationship between these changes and the steroidome. Methods: The study was conducted on a clinically homogeneous group of 41 females around their sixth decade, diagnosed with anxiety-depressive syndrome and treated with selective serotonin reuptake inhibitors (SSRIs). Postural balance was assessed using the dual-scales method (DLLL-DSM), which estimates postural imbalance by evaluating differences in the lower limb load in the standing position. Correlations between initial DLLL-DSM values, age, BMI, and the baseline levels of nine serum steroids, as well as post-intervention changes in five steroids, were analyzed using multivariate regression (OPLS model). Results: A significant reduction in lower limb load differences (-ΔDLLL-DSM), indicating improved postural balance, was observed. The -ΔDLLL-DSM strongly correlated with initial DLLL-DSM values, age, BMI, initial levels of nine serum steroids, and post-intervention changes in five steroids (R = 0.892, <i>p</i> < 0.001). Furthermore, initial DLLL-DSM values negatively correlated with adrenal androgen androstenediol sulfate and various sulfated 5α/β-reduced androgen metabolites (R = 0.323, <i>p</i> < 0.05), suggesting that the activity of steroid sulfotransferase (SULT2A1) and C17-hydroxylase-C17,20-lyase (CYP17A1) at the lyase step is negatively associated with postural imbalance in elderly females. Conclusions: The findings suggest that even severe postural imbalance can be effectively and relatively rapidly improved through an appropriate exercise-based intervention and an optimized daily regimen, provided that initial adrenal activity is not significantly impaired. Additionally, the identified associations between steroid levels and postural balance provide new insights into the hormonal mechanisms regulating balance control in older individuals.https://www.mdpi.com/2218-1989/15/4/239static postural balanceagingexercise interventionsteroidomegas chromatography-tandem mass spectrometrymultivariate statistics |
| spellingShingle | Zuzanna Kornatovská Martin Hill Dobroslava Jandová Milada Krejčí Anna Zwierzchowska Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female Metabolites static postural balance aging exercise intervention steroidome gas chromatography-tandem mass spectrometry multivariate statistics |
| title | Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female |
| title_full | Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female |
| title_fullStr | Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female |
| title_full_unstemmed | Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female |
| title_short | Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female |
| title_sort | steroids static postural balance changes after exercise intervention correlate with steroidome in elderly female |
| topic | static postural balance aging exercise intervention steroidome gas chromatography-tandem mass spectrometry multivariate statistics |
| url | https://www.mdpi.com/2218-1989/15/4/239 |
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