Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products
The article covers microbiological methods that help assess the biological activity of antibiotics, which is fundamental for determination of clinical efficacy of antimicrobial drugs. The authors chose gentamicin, an aminoglycoside antibiotic, to illustrate the development and validation of the turb...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/99 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849692733969530880 |
|---|---|
| author | Yu. V. Olefir E. N. Semenova S. I. Kuleshova E. I. Sakanyan S. A. Protsak |
| author_facet | Yu. V. Olefir E. N. Semenova S. I. Kuleshova E. I. Sakanyan S. A. Protsak |
| author_sort | Yu. V. Olefir |
| collection | DOAJ |
| description | The article covers microbiological methods that help assess the biological activity of antibiotics, which is fundamental for determination of clinical efficacy of antimicrobial drugs. The authors chose gentamicin, an aminoglycoside antibiotic, to illustrate the development and validation of the turbidimetric assay, which is based on antibiotic's inhibitory effect on the growth of Staphylococcus aureus ATCC 6538Р test strain in liquid medium. The obtained data were assessed with ANOVA and were recognized as linear (r=0.9921) in the concentration range of 0.64-1.56 mg/ml. The results of gentamicin assay validation studies demonstrate great potential and applicability of the turbidimetric method for standardization and ensuing quality control of aminoglycoside antibiotics. |
| format | Article |
| id | doaj-art-8680e36fa6314cbf92d2a363fc139777 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-8680e36fa6314cbf92d2a363fc1397772025-08-20T03:20:37ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01637-8626698Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based ProductsYu. V. Olefir0E. N. Semenova1S. I. Kuleshova2E. I. Sakanyan3S. A. Protsak4Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationScientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationScientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationScientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationScientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationThe article covers microbiological methods that help assess the biological activity of antibiotics, which is fundamental for determination of clinical efficacy of antimicrobial drugs. The authors chose gentamicin, an aminoglycoside antibiotic, to illustrate the development and validation of the turbidimetric assay, which is based on antibiotic's inhibitory effect on the growth of Staphylococcus aureus ATCC 6538Р test strain in liquid medium. The obtained data were assessed with ANOVA and were recognized as linear (r=0.9921) in the concentration range of 0.64-1.56 mg/ml. The results of gentamicin assay validation studies demonstrate great potential and applicability of the turbidimetric method for standardization and ensuing quality control of aminoglycoside antibiotics.https://www.antibiotics-chemotherapy.ru/jour/article/view/99aminoglycoside antibioticassayturbidimetric methodstandardizationquality control |
| spellingShingle | Yu. V. Olefir E. N. Semenova S. I. Kuleshova E. I. Sakanyan S. A. Protsak Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products Антибиотики и Химиотерапия aminoglycoside antibiotic assay turbidimetric method standardization quality control |
| title | Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products |
| title_full | Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products |
| title_fullStr | Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products |
| title_full_unstemmed | Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products |
| title_short | Turbidimetric Method for Standardization and Quality Control of Aminoglycoside Antibiotics and Aminoglycoside-Based Products |
| title_sort | turbidimetric method for standardization and quality control of aminoglycoside antibiotics and aminoglycoside based products |
| topic | aminoglycoside antibiotic assay turbidimetric method standardization quality control |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/99 |
| work_keys_str_mv | AT yuvolefir turbidimetricmethodforstandardizationandqualitycontrolofaminoglycosideantibioticsandaminoglycosidebasedproducts AT ensemenova turbidimetricmethodforstandardizationandqualitycontrolofaminoglycosideantibioticsandaminoglycosidebasedproducts AT sikuleshova turbidimetricmethodforstandardizationandqualitycontrolofaminoglycosideantibioticsandaminoglycosidebasedproducts AT eisakanyan turbidimetricmethodforstandardizationandqualitycontrolofaminoglycosideantibioticsandaminoglycosidebasedproducts AT saprotsak turbidimetricmethodforstandardizationandqualitycontrolofaminoglycosideantibioticsandaminoglycosidebasedproducts |