A mutational process signature and genomic alterations associated with outcome and immunogenicity in cancers with brain metastasis

A mutational process signature and genomic alterations associated with outcome and immunogenicity in cancers with brain metastasis

BackgroundBrain metastasis (BM) is one of the common ways of tumor metastasis and has a poor prognosis. This study aims to identify potential biomarkers from the perspective of somatic mutations, providing a basis for the prognosis evaluation and immunogenicity prediction of BM patients.MethodsThis...

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Bibliographic Details
Main Authors: Wanli Sun, Xueying Wang, Yixin Xu, Yanfeng Ren, Wenjing Zhang, Qinghua Wang, Yingzhi Chong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
brain metastasis
prognosticators
mutational signatures
molecular subtypes
genomic variations
tumor immunogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607772/full
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