Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy
Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments to address the diverse needs and concerns of individuals. Transdermal delivery technology offers a promising alternative compared to...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/16/11/1384 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850068544508657664 |
|---|---|
| author | Yunxiang Kang Sunxin Zhang Guoqi Wang Ziwei Yan Guyuan Wu Lu Tang Wei Wang |
| author_facet | Yunxiang Kang Sunxin Zhang Guoqi Wang Ziwei Yan Guyuan Wu Lu Tang Wei Wang |
| author_sort | Yunxiang Kang |
| collection | DOAJ |
| description | Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments to address the diverse needs and concerns of individuals. Transdermal delivery technology offers a promising alternative compared to traditional administration methods such as oral or injection routes. Therefore, this review focuses on the recent achievements of nanocarrier-based transdermal delivery technology for dermatological therapy, which summarizes diverse delivery strategies to enhance skin penetration using various nanocarriers including vesicular nanocarriers, lipid-based nanocarriers, emulsion-based nanocarriers, and polymeric nanocarrier according to the pathogenesis of common dermatoses. The fundamentals of transdermal delivery including skin physiology structure and routes of penetration are introduced. Moreover, mechanisms to enhance skin penetration due to the utilization of nanocarriers such as skin hydration, system deformability, disruption of the stratum corneum, surface charge, and tunable particle size are outlined as well. |
| format | Article |
| id | doaj-art-86789a755ca94fda80ce8bf910d62d8a |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-86789a755ca94fda80ce8bf910d62d8a2025-08-20T02:48:02ZengMDPI AGPharmaceutics1999-49232024-10-011611138410.3390/pharmaceutics16111384Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological TherapyYunxiang Kang0Sunxin Zhang1Guoqi Wang2Ziwei Yan3Guyuan Wu4Lu Tang5Wei Wang6NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaNMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaNMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaNMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaNMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaNMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaNMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, ChinaDermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments to address the diverse needs and concerns of individuals. Transdermal delivery technology offers a promising alternative compared to traditional administration methods such as oral or injection routes. Therefore, this review focuses on the recent achievements of nanocarrier-based transdermal delivery technology for dermatological therapy, which summarizes diverse delivery strategies to enhance skin penetration using various nanocarriers including vesicular nanocarriers, lipid-based nanocarriers, emulsion-based nanocarriers, and polymeric nanocarrier according to the pathogenesis of common dermatoses. The fundamentals of transdermal delivery including skin physiology structure and routes of penetration are introduced. Moreover, mechanisms to enhance skin penetration due to the utilization of nanocarriers such as skin hydration, system deformability, disruption of the stratum corneum, surface charge, and tunable particle size are outlined as well.https://www.mdpi.com/1999-4923/16/11/1384dermatological therapynanocarrierskin penetrationtransdermal delivery |
| spellingShingle | Yunxiang Kang Sunxin Zhang Guoqi Wang Ziwei Yan Guyuan Wu Lu Tang Wei Wang Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy Pharmaceutics dermatological therapy nanocarrier skin penetration transdermal delivery |
| title | Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy |
| title_full | Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy |
| title_fullStr | Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy |
| title_full_unstemmed | Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy |
| title_short | Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy |
| title_sort | nanocarrier based transdermal drug delivery systems for dermatological therapy |
| topic | dermatological therapy nanocarrier skin penetration transdermal delivery |
| url | https://www.mdpi.com/1999-4923/16/11/1384 |
| work_keys_str_mv | AT yunxiangkang nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy AT sunxinzhang nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy AT guoqiwang nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy AT ziweiyan nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy AT guyuanwu nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy AT lutang nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy AT weiwang nanocarrierbasedtransdermaldrugdeliverysystemsfordermatologicaltherapy |