Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma
Secondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis. Outcomes of radiation-induced sGBM remain poor in both children and adults. We report a cas...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/290905 |
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| author | C. S. Amene L. A. Yeh-Nayre J. R. Crawford |
| author_facet | C. S. Amene L. A. Yeh-Nayre J. R. Crawford |
| author_sort | C. S. Amene |
| collection | DOAJ |
| description | Secondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis. Outcomes of radiation-induced sGBM remain poor in both children and adults. We report a case of a 16-year-old girl with a history of disseminated juvenile pilocytic astrocytoma treated with chemotherapy and craniospinal radiation 9 years prior who developed sGBM in the absence of a tumor predisposition syndrome. She presented with a several-week history of headaches and no acute findings on computed tomography compared to baseline neuroimaging 3 months prior. Repeat computed tomography performed just 3 weeks later for worsening headaches revealed a new large posterior fossa tumor where pathology confirmed the diagnosis of sGBM. In spite of maximal surgical resection, reirradiation, and adjuvant chemotherapy, she died 1 year postdiagnosis. Our case highlights the potential late effects of high-dose cranial radiation, how symptomatology may precede neuroimaging findings, and the rapid formation of sGBM that mirrors that of de novo Glioblastoma Multiforme. |
| format | Article |
| id | doaj-art-866e361dac434a1fb664057136953140 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-866e361dac434a1fb6640571369531402025-02-03T00:59:32ZengWileyCase Reports in Oncological Medicine2090-67062090-67142012-01-01201210.1155/2012/290905290905Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic AstrocytomaC. S. Amene0L. A. Yeh-Nayre1J. R. Crawford2The Departments of Neurosurgery, San Diego and Rady Children’s Hospital, University of California, 3020 Children's Way San Diego, San Diego, CA 92123, USAThe Departments of Pediatrics, San Diego and Rady Children’s Hospital, University of California, 3020 Children's Way San Diego, San Diego, CA 92123, USAThe Departments of Pediatrics, San Diego and Rady Children’s Hospital, University of California, 3020 Children's Way San Diego, San Diego, CA 92123, USASecondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis. Outcomes of radiation-induced sGBM remain poor in both children and adults. We report a case of a 16-year-old girl with a history of disseminated juvenile pilocytic astrocytoma treated with chemotherapy and craniospinal radiation 9 years prior who developed sGBM in the absence of a tumor predisposition syndrome. She presented with a several-week history of headaches and no acute findings on computed tomography compared to baseline neuroimaging 3 months prior. Repeat computed tomography performed just 3 weeks later for worsening headaches revealed a new large posterior fossa tumor where pathology confirmed the diagnosis of sGBM. In spite of maximal surgical resection, reirradiation, and adjuvant chemotherapy, she died 1 year postdiagnosis. Our case highlights the potential late effects of high-dose cranial radiation, how symptomatology may precede neuroimaging findings, and the rapid formation of sGBM that mirrors that of de novo Glioblastoma Multiforme.http://dx.doi.org/10.1155/2012/290905 |
| spellingShingle | C. S. Amene L. A. Yeh-Nayre J. R. Crawford Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma Case Reports in Oncological Medicine |
| title | Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma |
| title_full | Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma |
| title_fullStr | Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma |
| title_full_unstemmed | Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma |
| title_short | Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma |
| title_sort | secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma |
| url | http://dx.doi.org/10.1155/2012/290905 |
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