Release of siRNA from Liposomes Induced by Curcumin
Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes enca...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2016/7051523 |
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| _version_ | 1832561987522920448 |
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| author | Kazuyo Fujita Yoshie Hiramatsu Hideki Minematsu Masaharu Somiya Shun’ichi Kuroda Masaharu Seno Shuji Hinuma |
| author_facet | Kazuyo Fujita Yoshie Hiramatsu Hideki Minematsu Masaharu Somiya Shun’ichi Kuroda Masaharu Seno Shuji Hinuma |
| author_sort | Kazuyo Fujita |
| collection | DOAJ |
| description | Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA. |
| format | Article |
| id | doaj-art-866cf6b55f244495ae7d20f203301ceb |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-866cf6b55f244495ae7d20f203301ceb2025-02-03T01:23:43ZengWileyJournal of Nanotechnology1687-95031687-95112016-01-01201610.1155/2016/70515237051523Release of siRNA from Liposomes Induced by CurcuminKazuyo Fujita0Yoshie Hiramatsu1Hideki Minematsu2Masaharu Somiya3Shun’ichi Kuroda4Masaharu Seno5Shuji Hinuma6Department of Food and Nutrition, Faculty of Human Life Science, Senri Kinran University, Fujishirodai, Suita City, Osaka, JapanR&D Division, Katayama Chemical Industries, Co., Ltd., Ina, Minoh City, Osaka, JapanR&D Division, Katayama Chemical Industries, Co., Ltd., Ina, Minoh City, Osaka, JapanDepartment of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya City, Aichi, JapanDepartment of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya City, Aichi, JapanDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama City, Okayama, JapanDepartment of Food and Nutrition, Faculty of Human Life Science, Senri Kinran University, Fujishirodai, Suita City, Osaka, JapanLiposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.http://dx.doi.org/10.1155/2016/7051523 |
| spellingShingle | Kazuyo Fujita Yoshie Hiramatsu Hideki Minematsu Masaharu Somiya Shun’ichi Kuroda Masaharu Seno Shuji Hinuma Release of siRNA from Liposomes Induced by Curcumin Journal of Nanotechnology |
| title | Release of siRNA from Liposomes Induced by Curcumin |
| title_full | Release of siRNA from Liposomes Induced by Curcumin |
| title_fullStr | Release of siRNA from Liposomes Induced by Curcumin |
| title_full_unstemmed | Release of siRNA from Liposomes Induced by Curcumin |
| title_short | Release of siRNA from Liposomes Induced by Curcumin |
| title_sort | release of sirna from liposomes induced by curcumin |
| url | http://dx.doi.org/10.1155/2016/7051523 |
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