Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia
Abstract Objective Previous studies have shown that the lactate/albumin ratio (LAR) can be a prognostic biomarker in intensive care unit (ICU) patients. However, the usefulness of LAR in predicting mortality and guiding intensive care unit admission in hospitalized patients due to community-acquired...
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2025-05-01
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| Online Access: | https://doi.org/10.1186/s12890-025-03698-7 |
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| author | Pervin Hancı Esra Temel Furkan Bilir Bilkay Serez Kaya |
| author_facet | Pervin Hancı Esra Temel Furkan Bilir Bilkay Serez Kaya |
| author_sort | Pervin Hancı |
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| description | Abstract Objective Previous studies have shown that the lactate/albumin ratio (LAR) can be a prognostic biomarker in intensive care unit (ICU) patients. However, the usefulness of LAR in predicting mortality and guiding intensive care unit admission in hospitalized patients due to community-acquired pneumonia (CAP) remains unclear. This study aims to evaluate the predictive value of the LAR compared to Pneumonia Severity Index (PSI), Confusion, urea, respiratory rate, blood pressure, 65 years or older (CURB-65), and quick-Sequential Organ Failure Assessment (q-SOFA) scores in determining the need for ICU admission and mortality among hospitalized patients with CAP. Methods Adult patients diagnosed and hospitalized with community-acquired pneumonia between July 2021 and July 2023 were included. Patients’ demographics, comorbidities, disease severity scores, laboratory findings at the admission and outcomes were recorded. Patients were grouped and compared according to admission place (ward or ICU). Results PSI, CURB-65, q-SOFA scores, and LAR were higher in ICU patients than in those admitted to the ward. Regarding the ICU admission, the AUC values for PSI, CURB-65, q-SOFA and LAR were 0.794 (95% CI: 0.737–0.843) (p < 0.001), 0.825 (95% CI: 0.771–0.870) (p < 0.001), 0.755 (0.690–0.813) (p < 0.001), and 0.749 (95% CI: 0.689–0.802) (p < 0.001), respectively. Regarding the mortality, the AUC values for PSI, CURB-65, q-SOFA, and LAR were 0.722 (95% CI: 0.661–0.778) (p < 0.001), 0.743 (95% CI: 0.683–0.797) (p < 0.001), 0.645 (0.575–0.711) (p: 0.02), 0.761 (95% CI: 0.702–0.814) (p < 0.001), respectively. There wasn’t any difference detected in pairwise comparisons of ROC curves. Conclusion In this study, LAR was found to be a good predictor of ICU admissions and mortality in hospitalized patients with CAP and was non-inferior to PSI, CURB-65, or q-SOFA scores. |
| format | Article |
| id | doaj-art-865e5c1daead4e3988e2fbb71e82c57d |
| institution | DOAJ |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Pulmonary Medicine |
| spelling | doaj-art-865e5c1daead4e3988e2fbb71e82c57d2025-08-20T03:09:34ZengBMCBMC Pulmonary Medicine1471-24662025-05-012511710.1186/s12890-025-03698-7Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumoniaPervin Hancı0Esra Temel1Furkan Bilir2Bilkay Serez Kaya3Department of Pulmonary Medicine and Division of Intensive Care, Trakya University Faculty of Medicine, Trakya University Medical Research and Application CentreDepartment of Pulmonology, Trakya University Faculty of MedicineDepartment of Pulmonology, Trakya University Faculty of MedicineDepartment of Pulmonology, Trakya University Faculty of MedicineAbstract Objective Previous studies have shown that the lactate/albumin ratio (LAR) can be a prognostic biomarker in intensive care unit (ICU) patients. However, the usefulness of LAR in predicting mortality and guiding intensive care unit admission in hospitalized patients due to community-acquired pneumonia (CAP) remains unclear. This study aims to evaluate the predictive value of the LAR compared to Pneumonia Severity Index (PSI), Confusion, urea, respiratory rate, blood pressure, 65 years or older (CURB-65), and quick-Sequential Organ Failure Assessment (q-SOFA) scores in determining the need for ICU admission and mortality among hospitalized patients with CAP. Methods Adult patients diagnosed and hospitalized with community-acquired pneumonia between July 2021 and July 2023 were included. Patients’ demographics, comorbidities, disease severity scores, laboratory findings at the admission and outcomes were recorded. Patients were grouped and compared according to admission place (ward or ICU). Results PSI, CURB-65, q-SOFA scores, and LAR were higher in ICU patients than in those admitted to the ward. Regarding the ICU admission, the AUC values for PSI, CURB-65, q-SOFA and LAR were 0.794 (95% CI: 0.737–0.843) (p < 0.001), 0.825 (95% CI: 0.771–0.870) (p < 0.001), 0.755 (0.690–0.813) (p < 0.001), and 0.749 (95% CI: 0.689–0.802) (p < 0.001), respectively. Regarding the mortality, the AUC values for PSI, CURB-65, q-SOFA, and LAR were 0.722 (95% CI: 0.661–0.778) (p < 0.001), 0.743 (95% CI: 0.683–0.797) (p < 0.001), 0.645 (0.575–0.711) (p: 0.02), 0.761 (95% CI: 0.702–0.814) (p < 0.001), respectively. There wasn’t any difference detected in pairwise comparisons of ROC curves. Conclusion In this study, LAR was found to be a good predictor of ICU admissions and mortality in hospitalized patients with CAP and was non-inferior to PSI, CURB-65, or q-SOFA scores.https://doi.org/10.1186/s12890-025-03698-7PneumoniaIntensive care unitsHospitalizationMortalityLactateAlbumin |
| spellingShingle | Pervin Hancı Esra Temel Furkan Bilir Bilkay Serez Kaya Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia BMC Pulmonary Medicine Pneumonia Intensive care units Hospitalization Mortality Lactate Albumin |
| title | Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia |
| title_full | Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia |
| title_fullStr | Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia |
| title_full_unstemmed | Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia |
| title_short | Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia |
| title_sort | lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community acquired pneumonia |
| topic | Pneumonia Intensive care units Hospitalization Mortality Lactate Albumin |
| url | https://doi.org/10.1186/s12890-025-03698-7 |
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