A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy
Background: Lymphocyte to neutrophil ratio (NLR) is a rapid and simple marker for systemic inflammation and stress after major surgery. In this study, we aimed to compare NLR changes according to surgical methods of hysterectomy. Methods: A retrospective chart review for all patients who underwent h...
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IMR Press
2022-01-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/49/1/10.31083/j.ceog4901010 |
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| author | Hyesook Kim Hye-yon Cho Soo Young Jeong Sung Taek Park Sung-ho Park |
| author_facet | Hyesook Kim Hye-yon Cho Soo Young Jeong Sung Taek Park Sung-ho Park |
| author_sort | Hyesook Kim |
| collection | DOAJ |
| description | Background: Lymphocyte to neutrophil ratio (NLR) is a rapid and simple marker for systemic inflammation and stress after major surgery. In this study, we aimed to compare NLR changes according to surgical methods of hysterectomy. Methods: A retrospective chart review for all patients who underwent hysterectomy for benign uterine disease from 2016 to 2020 was performed. A total of 1549 women were assigned to total laparoscopic hysterectomy (TLH) (n = 419), vaginal hysterectomy (VH) (n = 608), and total abdominal hysterectomy (TAH) (n = 522) groups. Patient characteristics, surgical outcomes, and NLR changes were compared among women who underwent TLH, VH, and TAH. Results: Preoperative mean NLR was similar among three groups (p = 0.056). However, mean NLR on postoperative day 1 (p< 0.0001) and day 3 (p = 0.011) was significantly lower in TLH group than others. Also, mean NLR change on postoperative day 1 was significantly lesser in TLH group than others (1.9 in TLH vs. 5.4 in VH vs. 4.7 in TAH; p < 0.0001). Mean NLR change on postoperative day 3 was greater in TAH group than others, although there were no statistically significant differences (0.2 in TLH vs. 0.3 in VH vs. 0.7 in TAH; p = 0.354). Multivariate analysis revealed that massive NLR change (>5.0) on postoperative day 1 was significantly associated with types of hysterectomy (p < 0.0001). Conclusion: Our data showed that acute NLR change was lesser in TLH group comparing to VH and TAH group, which suggests that TLH might be associated with less systemic inflammation and tissue trauma after surgery. |
| format | Article |
| id | doaj-art-865dbaf2a9c6474b903deebfa3043a38 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-865dbaf2a9c6474b903deebfa3043a382025-08-20T01:58:24ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-01-014911010.31083/j.ceog4901010S0390-6663(22)01660-8A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomyHyesook Kim0Hye-yon Cho1Soo Young Jeong2Sung Taek Park3Sung-ho Park4Institute of New Frontier Research Team, Hallym University, 24252 Chuncheon, Republic of KoreaDepartment of Obstetrics and Gynecology, Hallym University, 24262 Seoul, Republic of KoreaInstitute of New Frontier Research Team, Hallym University, 24252 Chuncheon, Republic of KoreaInstitute of New Frontier Research Team, Hallym University, 24252 Chuncheon, Republic of KoreaDepartment of Obstetrics and Gynecology, Hallym University, 24262 Seoul, Republic of KoreaBackground: Lymphocyte to neutrophil ratio (NLR) is a rapid and simple marker for systemic inflammation and stress after major surgery. In this study, we aimed to compare NLR changes according to surgical methods of hysterectomy. Methods: A retrospective chart review for all patients who underwent hysterectomy for benign uterine disease from 2016 to 2020 was performed. A total of 1549 women were assigned to total laparoscopic hysterectomy (TLH) (n = 419), vaginal hysterectomy (VH) (n = 608), and total abdominal hysterectomy (TAH) (n = 522) groups. Patient characteristics, surgical outcomes, and NLR changes were compared among women who underwent TLH, VH, and TAH. Results: Preoperative mean NLR was similar among three groups (p = 0.056). However, mean NLR on postoperative day 1 (p< 0.0001) and day 3 (p = 0.011) was significantly lower in TLH group than others. Also, mean NLR change on postoperative day 1 was significantly lesser in TLH group than others (1.9 in TLH vs. 5.4 in VH vs. 4.7 in TAH; p < 0.0001). Mean NLR change on postoperative day 3 was greater in TAH group than others, although there were no statistically significant differences (0.2 in TLH vs. 0.3 in VH vs. 0.7 in TAH; p = 0.354). Multivariate analysis revealed that massive NLR change (>5.0) on postoperative day 1 was significantly associated with types of hysterectomy (p < 0.0001). Conclusion: Our data showed that acute NLR change was lesser in TLH group comparing to VH and TAH group, which suggests that TLH might be associated with less systemic inflammation and tissue trauma after surgery.https://www.imrpress.com/journal/CEOG/49/1/10.31083/j.ceog4901010neutrophil-to-lymphocyte ratiosystemic inflammatory responsehysterectomy |
| spellingShingle | Hyesook Kim Hye-yon Cho Soo Young Jeong Sung Taek Park Sung-ho Park A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy Clinical and Experimental Obstetrics & Gynecology neutrophil-to-lymphocyte ratio systemic inflammatory response hysterectomy |
| title | A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy |
| title_full | A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy |
| title_fullStr | A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy |
| title_full_unstemmed | A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy |
| title_short | A retrospective comparative analysis of systemic inflammatory responseafter laparoscopic, vaginal, and abdominal hysterectomy |
| title_sort | retrospective comparative analysis of systemic inflammatory responseafter laparoscopic vaginal and abdominal hysterectomy |
| topic | neutrophil-to-lymphocyte ratio systemic inflammatory response hysterectomy |
| url | https://www.imrpress.com/journal/CEOG/49/1/10.31083/j.ceog4901010 |
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