Ferroptosis and its implications in bone-related diseases
Ferroptosis, a recently recognized form of regulated cell death (RCD) characterized by iron-dependent lipid peroxide accumulation, has emerged as a noteworthy regulator in various bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), and osteosarcoma (OS). OS primarily afflicts th...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2024-11-01
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| Online Access: | https://peerj.com/articles/18626.pdf |
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| author | Zihao Wang Qiupeng Yan Zhen Wang Zunguo Hu Chenchen Wang Xue Zhang Xueshuai Gao Xue Bai Xiaosu Chen Lingyun Zhang Danyue Lv Huancai Liu Yanchun Chen |
| author_facet | Zihao Wang Qiupeng Yan Zhen Wang Zunguo Hu Chenchen Wang Xue Zhang Xueshuai Gao Xue Bai Xiaosu Chen Lingyun Zhang Danyue Lv Huancai Liu Yanchun Chen |
| author_sort | Zihao Wang |
| collection | DOAJ |
| description | Ferroptosis, a recently recognized form of regulated cell death (RCD) characterized by iron-dependent lipid peroxide accumulation, has emerged as a noteworthy regulator in various bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), and osteosarcoma (OS). OS primarily afflicts the elderly, rendering them susceptible to fractures due to increased bone fragility. OA represents the most prevalent arthritis in the world, often observed in the aging population. OS predominantly manifests during adolescence, exhibiting an aggressive nature and bearing a significantly unfavorable prognosis. In this review article, we present an overview of the characteristics and mechanism of ferroptosis and its involvement in bone-related diseases, with a particular focus on OP, OA, and OS. Furthermore, we summarize chemical compounds or biological factors that impact bone-related diseases by regulating ferroptosis. Through an in-depth exploration of ferroptosis based on current research findings, this review provides promising insights for potential therapeutic approaches to effectively manage and mitigate the impact of these bone-related pathological conditions. |
| format | Article |
| id | doaj-art-865d32f8740244f7bb6ca19b723c3d46 |
| institution | OA Journals |
| issn | 2167-8359 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-865d32f8740244f7bb6ca19b723c3d462025-08-20T02:07:08ZengPeerJ Inc.PeerJ2167-83592024-11-0112e1862610.7717/peerj.18626Ferroptosis and its implications in bone-related diseasesZihao Wang0Qiupeng Yan1Zhen Wang2Zunguo Hu3Chenchen Wang4Xue Zhang5Xueshuai Gao6Xue Bai7Xiaosu Chen8Lingyun Zhang9Danyue Lv10Huancai Liu11Yanchun Chen12Shandong Second Medical University, Department of Joint Surgery, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Department of Joint Surgery, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang, Shandong, ChinaShandong Second Medical University, Department of Joint Surgery, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaShandong Second Medical University, Clinical Medicine, School of Clinical Medicine, Weifang, Shandong, ChinaShandong Second Medical University, Department of Joint Surgery, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang, Shandong, ChinaShandong Second Medical University, Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Weifang, Shandong, ChinaFerroptosis, a recently recognized form of regulated cell death (RCD) characterized by iron-dependent lipid peroxide accumulation, has emerged as a noteworthy regulator in various bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), and osteosarcoma (OS). OS primarily afflicts the elderly, rendering them susceptible to fractures due to increased bone fragility. OA represents the most prevalent arthritis in the world, often observed in the aging population. OS predominantly manifests during adolescence, exhibiting an aggressive nature and bearing a significantly unfavorable prognosis. In this review article, we present an overview of the characteristics and mechanism of ferroptosis and its involvement in bone-related diseases, with a particular focus on OP, OA, and OS. Furthermore, we summarize chemical compounds or biological factors that impact bone-related diseases by regulating ferroptosis. Through an in-depth exploration of ferroptosis based on current research findings, this review provides promising insights for potential therapeutic approaches to effectively manage and mitigate the impact of these bone-related pathological conditions.https://peerj.com/articles/18626.pdfOsteoporosisOsteoarthritisOsteosarcomaFerroptosis |
| spellingShingle | Zihao Wang Qiupeng Yan Zhen Wang Zunguo Hu Chenchen Wang Xue Zhang Xueshuai Gao Xue Bai Xiaosu Chen Lingyun Zhang Danyue Lv Huancai Liu Yanchun Chen Ferroptosis and its implications in bone-related diseases PeerJ Osteoporosis Osteoarthritis Osteosarcoma Ferroptosis |
| title | Ferroptosis and its implications in bone-related diseases |
| title_full | Ferroptosis and its implications in bone-related diseases |
| title_fullStr | Ferroptosis and its implications in bone-related diseases |
| title_full_unstemmed | Ferroptosis and its implications in bone-related diseases |
| title_short | Ferroptosis and its implications in bone-related diseases |
| title_sort | ferroptosis and its implications in bone related diseases |
| topic | Osteoporosis Osteoarthritis Osteosarcoma Ferroptosis |
| url | https://peerj.com/articles/18626.pdf |
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