mTOR Inhibition limits LPS induced acute kidney injury and ameliorates hallmarks of cellular senescence

mTOR Inhibition limits LPS induced acute kidney injury and ameliorates hallmarks of cellular senescence

Abstract Sepsis-induced acute kidney injury (AKI) can lead to chronic renal dysfunction with accelerated renal aging. Activation of the mammalian target of rapamycin (mTOR) is implicated in the initiation and progression of renal injury. This study investigates the effectiveness of the mTOR inhibito...

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Main Authors: Alessandra Stasi, Rossana Franzin, Fabio Sallustio, Alessandro Scagliotti, Paola Cappello, Elena Squiccimarro, Gianvito Caggiano, Rosa Losapio, Monica Campioni, Antonino Castellaneta, Vincenzo Cantaluppi, Claudia Curci, Paola Pontrelli, Giovanni Stallone, Loreto Gesualdo, Vito Fanelli, Giuseppe Castellano
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-93815-7
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