Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins

Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins

ABSTRACT Interlinked interactions between the viral capsid (CA), nucleoporins (Nups), and the antiviral protein myxovirus resistance 2 (MX2/MXB) influence human immunodeficiency virus 1 (HIV-1) nuclear entry and the outcome of infection. Although RANBP2/NUP358 has been repeatedly identified as a cri...

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Bibliographic Details
Main Authors: Haley Flick, Ananya Venbakkam, Parmit K. Singh, Bailey Layish, Szu-Wei Huang, Rajalingam Radhakrishnan, Mamuka Kvaratskhelia, Alan N. Engelman, Melissa Kane
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
Subjects:
RANBP2
MX2
HIV-1 capsid
cyclophilin
Online Access:https://journals.asm.org/doi/10.1128/mbio.02646-24
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