ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) present in multiple tissues can self-renew and differentiate into multiple lineages including the bone, cartilage, muscle, cardiac tissue, and connective tissue. Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precis...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8839703 |
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| _version_ | 1832550988450365440 |
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| author | Wen Du Daimo Guo Wei Du |
| author_facet | Wen Du Daimo Guo Wei Du |
| author_sort | Wen Du |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) present in multiple tissues can self-renew and differentiate into multiple lineages including the bone, cartilage, muscle, cardiac tissue, and connective tissue. Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precise gene expression regulation. ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. ATP-dependent chromatin remodeling complexes consist of a variety of subunits that together perform multiple functions in self-renewal and lineage specification. This review highlights the important role of ATP-dependent chromatin remodeling complexes and their different subunits in modulating MSC fate determination and discusses the proposed mechanisms by which ATP-dependent chromatin remodelers function. |
| format | Article |
| id | doaj-art-8656a9eb5adb41a8bf278b944698c74c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8656a9eb5adb41a8bf278b944698c74c2025-02-03T06:05:18ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88397038839703ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem CellsWen Du0Daimo Guo1Wei Du2State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaMesenchymal stem cells (MSCs) present in multiple tissues can self-renew and differentiate into multiple lineages including the bone, cartilage, muscle, cardiac tissue, and connective tissue. Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precise gene expression regulation. ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. ATP-dependent chromatin remodeling complexes consist of a variety of subunits that together perform multiple functions in self-renewal and lineage specification. This review highlights the important role of ATP-dependent chromatin remodeling complexes and their different subunits in modulating MSC fate determination and discusses the proposed mechanisms by which ATP-dependent chromatin remodelers function.http://dx.doi.org/10.1155/2020/8839703 |
| spellingShingle | Wen Du Daimo Guo Wei Du ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells Stem Cells International |
| title | ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells |
| title_full | ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells |
| title_fullStr | ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells |
| title_full_unstemmed | ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells |
| title_short | ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells |
| title_sort | atp dependent chromatin remodeling complex in the lineage specification of mesenchymal stem cells |
| url | http://dx.doi.org/10.1155/2020/8839703 |
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