Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes
As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr3 or GaCl3 resulted in the mononuclear...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/168030 |
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| author | Stergios Zanias Giannis S. Papaefstathiou Catherine P. Raptopoulou Konstantinos T. Papazisis Vasiliki Vala Dimitra Zambouli Alexandros H. Kortsaris Dimitrios A. Kyriakidis Theodoros F. Zafiropoulos |
| author_facet | Stergios Zanias Giannis S. Papaefstathiou Catherine P. Raptopoulou Konstantinos T. Papazisis Vasiliki Vala Dimitra Zambouli Alexandros H. Kortsaris Dimitrios A. Kyriakidis Theodoros F. Zafiropoulos |
| author_sort | Stergios Zanias |
| collection | DOAJ |
| description | As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr3 or GaCl3 resulted in the mononuclear complexes [GaBr3(btaH)2] (1) and [GaCl3(btd)2] (2), respectively, while treatment of GaCl3 with L resulted in the anionic complex (LH)2[GaCl4] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines. |
| format | Article |
| id | doaj-art-8656708668844cd8b3ed8723b449e0c6 |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-8656708668844cd8b3ed8723b449e0c62025-08-20T02:08:47ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/168030168030Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole ComplexesStergios Zanias0Giannis S. Papaefstathiou1Catherine P. Raptopoulou2Konstantinos T. Papazisis3Vasiliki Vala4Dimitra Zambouli5Alexandros H. Kortsaris6Dimitrios A. Kyriakidis7Theodoros F. Zafiropoulos8Department of Chemistry, University of Patras, 265 04 Patras, GreeceLaboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, GreeceInstitute of Materials Science, NCSR “Demokritos”, 153 10 Aghia Paraskevi Attikis, Greece“Theagenion” Cancer Hospital, Al. Simeonides str. 2, 540 07 Thessaloniki, Greece“Theagenion” Cancer Hospital, Al. Simeonides str. 2, 540 07 Thessaloniki, Greece“Theagenion” Cancer Hospital, Al. Simeonides str. 2, 540 07 Thessaloniki, Greece“Theagenion” Cancer Hospital, Al. Simeonides str. 2, 540 07 Thessaloniki, GreeceDepartment of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, GreeceDepartment of Chemistry, University of Patras, 265 04 Patras, GreeceAs part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr3 or GaCl3 resulted in the mononuclear complexes [GaBr3(btaH)2] (1) and [GaCl3(btd)2] (2), respectively, while treatment of GaCl3 with L resulted in the anionic complex (LH)2[GaCl4] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.http://dx.doi.org/10.1155/2010/168030 |
| spellingShingle | Stergios Zanias Giannis S. Papaefstathiou Catherine P. Raptopoulou Konstantinos T. Papazisis Vasiliki Vala Dimitra Zambouli Alexandros H. Kortsaris Dimitrios A. Kyriakidis Theodoros F. Zafiropoulos Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes |
| title_full | Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes |
| title_fullStr | Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes |
| title_full_unstemmed | Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes |
| title_short | Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes |
| title_sort | synthesis structure and antiproliferative activity of three gallium iii azole complexes |
| url | http://dx.doi.org/10.1155/2010/168030 |
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