Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application
<i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> extracts have demonstrated significant antioxidant and anti-aging activities. However, research on combining these three extracts in specific proportions to enhance their antioxidant and ant...
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2024-11-01
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| Series: | Cosmetics |
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| author | Natthanan Phupaisan Chadarat Ampasavate Surapol Natakankitkul Kanokwan Kiattisin |
| author_facet | Natthanan Phupaisan Chadarat Ampasavate Surapol Natakankitkul Kanokwan Kiattisin |
| author_sort | Natthanan Phupaisan |
| collection | DOAJ |
| description | <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> extracts have demonstrated significant antioxidant and anti-aging activities. However, research on combining these three extracts in specific proportions to enhance their antioxidant and anti-hyaluronidase effects remains limited. Therefore, this study aimed to determine the optimal proportions of <i>C. arabica</i>, <i>C. asiatica</i>, and <i>C. longa</i> extracts to maximize their combined antioxidant and anti-hyaluronidase activities. A two-level full factorial design was used to identify the optimal concentration ratios of the mixed extracts. The results indicated that all extracts influenced antioxidant activity, with the optimal proportions of <i>C. arabica</i>, <i>C. asiatica</i>, and <i>C. longa</i> extracts being 0.5:6:2 mg/mL, respectively. In addition, all factors affected hyaluronidase enzyme inhibition, with the optimal proportions for <i>C. arabica</i>, <i>C. asiatica</i>, and <i>C. longa</i> extracts being 10:10:5 mg/mL to achieve the best inhibition. In a photostability study on individual extracts, mixed extracts, and mixed extracts combined with sodium metabisulfite and bis-ethylhexyloxyphenol methoxyphenyl triazine, it was observed that preparing the mixed extracts and adding an antioxidant and a sunscreen agent helped reduce the photodegradation of phenolic compounds in the mixed extracts. Consequently, the stabilized mixed extracts could serve as raw materials in cosmetic products. |
| format | Article |
| id | doaj-art-8654404cc0cc486f990fe8882df73e33 |
| institution | DOAJ |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-8654404cc0cc486f990fe8882df73e332025-08-20T02:55:45ZengMDPI AGCosmetics2079-92842024-11-0111620110.3390/cosmetics11060201Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic ApplicationNatthanan Phupaisan0Chadarat Ampasavate1Surapol Natakankitkul2Kanokwan Kiattisin3Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand<i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> extracts have demonstrated significant antioxidant and anti-aging activities. However, research on combining these three extracts in specific proportions to enhance their antioxidant and anti-hyaluronidase effects remains limited. Therefore, this study aimed to determine the optimal proportions of <i>C. arabica</i>, <i>C. asiatica</i>, and <i>C. longa</i> extracts to maximize their combined antioxidant and anti-hyaluronidase activities. A two-level full factorial design was used to identify the optimal concentration ratios of the mixed extracts. The results indicated that all extracts influenced antioxidant activity, with the optimal proportions of <i>C. arabica</i>, <i>C. asiatica</i>, and <i>C. longa</i> extracts being 0.5:6:2 mg/mL, respectively. In addition, all factors affected hyaluronidase enzyme inhibition, with the optimal proportions for <i>C. arabica</i>, <i>C. asiatica</i>, and <i>C. longa</i> extracts being 10:10:5 mg/mL to achieve the best inhibition. In a photostability study on individual extracts, mixed extracts, and mixed extracts combined with sodium metabisulfite and bis-ethylhexyloxyphenol methoxyphenyl triazine, it was observed that preparing the mixed extracts and adding an antioxidant and a sunscreen agent helped reduce the photodegradation of phenolic compounds in the mixed extracts. Consequently, the stabilized mixed extracts could serve as raw materials in cosmetic products.https://www.mdpi.com/2079-9284/11/6/201<i>Centella asiatica</i><i>Coffea arabica</i><i>Curcuma longa</i>Design of experiments (DOE) experimental designantioxidantanti-hyaluronidase |
| spellingShingle | Natthanan Phupaisan Chadarat Ampasavate Surapol Natakankitkul Kanokwan Kiattisin Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application Cosmetics <i>Centella asiatica</i> <i>Coffea arabica</i> <i>Curcuma longa</i> Design of experiments (DOE) experimental design antioxidant anti-hyaluronidase |
| title | Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application |
| title_full | Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application |
| title_fullStr | Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application |
| title_full_unstemmed | Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application |
| title_short | Optimizing Antioxidant and Anti-Hyaluronidase Activities of Mixed <i>Coffea arabica</i>, <i>Centella asiatica</i>, and <i>Curcuma longa</i> Extracts for Cosmetic Application |
| title_sort | optimizing antioxidant and anti hyaluronidase activities of mixed i coffea arabica i i centella asiatica i and i curcuma longa i extracts for cosmetic application |
| topic | <i>Centella asiatica</i> <i>Coffea arabica</i> <i>Curcuma longa</i> Design of experiments (DOE) experimental design antioxidant anti-hyaluronidase |
| url | https://www.mdpi.com/2079-9284/11/6/201 |
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