Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Ventral Root Schwann Cell Survival Following Hydrogen Peroxide-Induced Cell Death

Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Ventral Root Schwann Cell Survival Following Hydrogen Peroxide-Induced Cell Death

Schwann cell (SC) transplantation shows promise in treating spinal cord injury as a pro-regenerative agent to allow host endogenous neurons to bridge over the lesion. However, SC transplants face significant oxidative stress facilitated by ROS in the lesion, leading to poor survival. deferoxamine me...

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Bibliographic Details
Main Authors: Yee Hang Ethan Ma, Abhinay R. Putta, Cyrus H. H. Chan, Stephen R. Vidman, Paula Monje, Giles W. Plant
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
Schwann cells
spinal cord injury
deferoxamine mesylate
oxidative stress
transplantation
Online Access:https://www.mdpi.com/2073-4409/14/6/461
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