Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population
BackgroundThe debate persists regarding whether metabolic dysfunction-associated steatotic liver disease (MASLD) actively contributes to coronary heart disease or merely acts as a passive indicator.ObjectiveThis research aims to clarify the relationship between liver fat accumulation, as quantified...
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Frontiers Media S.A.
2024-12-01
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| author | Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Yu Wang Pijun Yan Pijun Yan Pijun Yan Pijun Yan Pijun Yan Pijun Yan Yi Li Yi Li Yi Li Yi Li Yi Li Yi Li Zhuang Chen Nanwei Tong Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan |
| author_facet | Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Yu Wang Pijun Yan Pijun Yan Pijun Yan Pijun Yan Pijun Yan Pijun Yan Yi Li Yi Li Yi Li Yi Li Yi Li Yi Li Zhuang Chen Nanwei Tong Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan |
| author_sort | Ying Miao |
| collection | DOAJ |
| description | BackgroundThe debate persists regarding whether metabolic dysfunction-associated steatotic liver disease (MASLD) actively contributes to coronary heart disease or merely acts as a passive indicator.ObjectiveThis research aims to clarify the relationship between liver fat accumulation, as quantified by FLI, and the risk of developing coronary heart disease.MethodsConducted from April to November 2011, the REACTION project, spearheaded by the Endocrinology Branch of the Chinese Medical Association, focused on Chinese adults aged 40 and above. Comprehensive data collection employed both questionnaires and specialized medical equipment, covering physical measurements, blood pressure, and pertinent biochemical markers. The study population excluded those with pre-existing coronary heart disease and acute myocardial infarction. Based on the initial data, participants were segmented and grouped into three categories. Analytically, the study utilized Cox proportional hazards models, further enhanced by stratified analyses to identify variations within predefined demographic groups.ResultsIn this study, we enrolled 8,647 participants, comprising 2,887 males and 5,760 females. Over the 10-year non-interventional follow-up period, 433 participants (5%) passed away due to various reasons, with 55 deaths attributed to coronary heart disease/myocardial infarction, accounting for 12.7% of total deaths. Additionally, 484 participants were diagnosed with new-onset coronary heart disease, resulting in an incidence rate of 5.5%. Spearman correlation analysis revealed a positive correlation between FLI and traditional risk factors for coronary heart disease, including age, male gender, abnormal glucose metabolism, hypertension, smoking, TG, TC, LDL-C, etc. The Log-rank test indicated a rising cumulative incidence of coronary heart disease with increasing FLI groupings (P<0.01). Moreover, Cox regression analysis highlighted a notable correlation between FLI levels as a risk factor and the onset of coronary heart disease. After adjusting for other risk factors, individuals in the 30≤FLI<60 group exhibited a 1.203-fold higher risk of coronary heart disease compared to those in the FLI<30 group (p=0.126), while participants in the FLI≥60 group had a 1.386-fold higher risk than those in the FLI<30 group (p=0.041).ConclusionElevated FLI values are strongly associated with an increased susceptibility to coronary heart disease, indicating its potential value as a prognostic marker for the condition. |
| format | Article |
| id | doaj-art-864a47ae793043bfbf1c8ce7717dbc87 |
| institution | DOAJ |
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| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-864a47ae793043bfbf1c8ce7717dbc872025-08-20T02:52:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.13678531367853Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese populationYing Miao0Ying Miao1Ying Miao2Ying Miao3Ying Miao4Ying Miao5Ying Miao6Yu Wang7Pijun Yan8Pijun Yan9Pijun Yan10Pijun Yan11Pijun Yan12Pijun Yan13Yi Li14Yi Li15Yi Li16Yi Li17Yi Li18Yi Li19Zhuang Chen20Nanwei Tong21Qin Wan22Qin Wan23Qin Wan24Qin Wan25Qin Wan26Qin Wan27Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaSouthwest Medical University, Luzhou, ChinaDepartment of Cardiology, Luzhou People’s Hospital, Luzhou, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaSouthwest Medical University, Luzhou, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaSouthwest Medical University, Luzhou, ChinaExperimental Medicine Center, the Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaSouthwest Medical University, Luzhou, ChinaBackgroundThe debate persists regarding whether metabolic dysfunction-associated steatotic liver disease (MASLD) actively contributes to coronary heart disease or merely acts as a passive indicator.ObjectiveThis research aims to clarify the relationship between liver fat accumulation, as quantified by FLI, and the risk of developing coronary heart disease.MethodsConducted from April to November 2011, the REACTION project, spearheaded by the Endocrinology Branch of the Chinese Medical Association, focused on Chinese adults aged 40 and above. Comprehensive data collection employed both questionnaires and specialized medical equipment, covering physical measurements, blood pressure, and pertinent biochemical markers. The study population excluded those with pre-existing coronary heart disease and acute myocardial infarction. Based on the initial data, participants were segmented and grouped into three categories. Analytically, the study utilized Cox proportional hazards models, further enhanced by stratified analyses to identify variations within predefined demographic groups.ResultsIn this study, we enrolled 8,647 participants, comprising 2,887 males and 5,760 females. Over the 10-year non-interventional follow-up period, 433 participants (5%) passed away due to various reasons, with 55 deaths attributed to coronary heart disease/myocardial infarction, accounting for 12.7% of total deaths. Additionally, 484 participants were diagnosed with new-onset coronary heart disease, resulting in an incidence rate of 5.5%. Spearman correlation analysis revealed a positive correlation between FLI and traditional risk factors for coronary heart disease, including age, male gender, abnormal glucose metabolism, hypertension, smoking, TG, TC, LDL-C, etc. The Log-rank test indicated a rising cumulative incidence of coronary heart disease with increasing FLI groupings (P<0.01). Moreover, Cox regression analysis highlighted a notable correlation between FLI levels as a risk factor and the onset of coronary heart disease. After adjusting for other risk factors, individuals in the 30≤FLI<60 group exhibited a 1.203-fold higher risk of coronary heart disease compared to those in the FLI<30 group (p=0.126), while participants in the FLI≥60 group had a 1.386-fold higher risk than those in the FLI<30 group (p=0.041).ConclusionElevated FLI values are strongly associated with an increased susceptibility to coronary heart disease, indicating its potential value as a prognostic marker for the condition.https://www.frontiersin.org/articles/10.3389/fendo.2024.1367853/fullthe Fatty Liver Indexcoronary heart diseasemetabolic dysfunction-associated steatotic liver diseaseREACTION projectChinese population |
| spellingShingle | Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Ying Miao Yu Wang Pijun Yan Pijun Yan Pijun Yan Pijun Yan Pijun Yan Pijun Yan Yi Li Yi Li Yi Li Yi Li Yi Li Yi Li Zhuang Chen Nanwei Tong Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population Frontiers in Endocrinology the Fatty Liver Index coronary heart disease metabolic dysfunction-associated steatotic liver disease REACTION project Chinese population |
| title | Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population |
| title_full | Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population |
| title_fullStr | Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population |
| title_full_unstemmed | Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population |
| title_short | Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population |
| title_sort | association between the fatty liver index fli and incident coronary heart disease insights from a cohort study on the chinese population |
| topic | the Fatty Liver Index coronary heart disease metabolic dysfunction-associated steatotic liver disease REACTION project Chinese population |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1367853/full |
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